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Institute of Medical Biotechnology
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  1. Friedrich-Alexander-Universität
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  3. Department Chemie- und Bioingenieurwesen
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  1. Friedrich-Alexander-Universität
  2. Technische Fakultät
  3. Department Chemie- und Bioingenieurwesen

Institute of Medical Biotechnology

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  4. High-throughput Biology & Robophotonics
  5. High-throughput Biology & Functional Neurogenomics

High-throughput Biology & Functional Neurogenomics

Bereichsnavigation: Research
  • Research Groups
    • Muscle Opto-Biomechatronics
      • The MyoRobot
      • The MechaMorph
      • The IsoStretcher
      • Virtual Laboratory
    • Malaria Biotechnology
      • RG Protein Engineering
      • Metabolic enzymes as drug targets
      • Identification of novel antimalarial compounds
      • Mitosis as drug target
      • Identification of transporters of the MGC-basic proteins
      • Characterization of drug-resistance transporters of the digestive vacuole
      • Malaria vaccine directed against blood stages
    • Tissue Engineering
      • Bone Tissue Engineering
      • Research Topic 2 (TE)
      • Research Topic 3 (TE)
    • Optical Technologies in Life Sciences
      • Label-free Multiphoton Imaging
      • Multiphoton Endomicroscopy for Life Science and Medicine
      • Raman Spectroscopy of Biological Tissue
      • PiezoGRIN: Multiphoton Imaging under high Pressures
    • High-throughput Biology & Robophotonics
      • High-throughput Biology & Functional Neurogenomics
      • Robophotonics & Rapid Prototyping
  • Collaborations
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High-throughput Biology & Functional Neurogenomics

Group Leader

Daniel Gilbert

PD Dr. Daniel F. Gilbert, Dipl. Biol.

Group Leader

Medical Biotechnology
High-throughput Biology & Rapid Prototyping

Raum: Room 00.112
Ulrich-Schalk-Str. 3
91056 Erlangen
Germany
  • Telefon: +46913185-23286-69655
  • E-Mail: daniel.gilbert@fau.de

Ion channel research

We are interested in chloride channels, in particular glycine and gamma-aminobutyric acid receptors (GlyR, GABAAR) and their role in homeostasis, development and disease. Glycine and GABAA receptors mediate inhibitory neurotransmission in the central nervous system (CNS). Dysfunction has been linked with neurological, neurodegenerative and psychiatric disease and is also associated with cancer. We use high-throughput and high-content screening technologies to identify genes involved in GlyR and GABAAR expression control as well as novel compounds active at those receptors. Chemical modulators of receptor function and expression can serve as leads for therapeutic development and as pharmacological tools for basic research, in research on synapse formation, homeostasis and plasticity as well as in developmental cell biology.

In-vitro research models

The development of pharmaceutical drugs involves animal experimentation. Novel medicines are required to be first tested on animals before clinical trials can be conducted. Identification of toxic compounds in early R&D using cell-based in vitro assays can reduce the number of laboratory animals used for in vivo testing of suboptimal compounds that fail at later stages of drug testing. We develop in vitro research methods according to the 3Rs concept – namely, Reduction, Refinement and Replacement of animal experimentation to minimize the need for animal testing. We strive to combine innovative screening assays utilizing the enormous potential of human pluripotent stem cells with massively parallelized microscopy technologies to reduce e.g. neurotoxicity testing in animals. These methods may also be less expensive and less time-consuming than animal testing.

Screening libraries

Under editing…

Friedrich-Alexander-Universität
Erlangen-Nürnberg

Schlossplatz 4
91054 Erlangen
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