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Institute of Medical Biotechnology
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  1. Friedrich-Alexander-Universität
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  3. Department Chemie- und Bioingenieurwesen
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  1. Friedrich-Alexander-Universität
  2. Technische Fakultät
  3. Department Chemie- und Bioingenieurwesen

Institute of Medical Biotechnology

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  2. Research
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  4. Muscle Opto-Biomechatronics

Muscle Opto-Biomechatronics

Bereichsnavigation: Research
  • Research Groups
    • Muscle Opto-Biomechatronics
      • The MyoRobot
      • The MechaMorph
      • The IsoStretcher
      • Virtual Laboratory
    • Malaria Biotechnology
      • RG Protein Engineering
      • Metabolic enzymes as drug targets
      • Identification of novel antimalarial compounds
      • Mitosis as drug target
      • Identification of transporters of the MGC-basic proteins
      • Characterization of drug-resistance transporters of the digestive vacuole
      • Malaria vaccine directed against blood stages
    • Tissue Engineering
      • Bone Tissue Engineering
      • Research Topic 2 (TE)
      • Research Topic 3 (TE)
    • Optical Technologies in Life Sciences
      • Label-free Multiphoton Imaging
      • Multiphoton Endomicroscopy for Life Science and Medicine
      • Raman Spectroscopy of Biological Tissue
      • PiezoGRIN: Multiphoton Imaging under high Pressures
    • High-throughput Biology & Robophotonics
      • High-throughput Biology & Functional Neurogenomics
      • Robophotonics & Rapid Prototyping
  • Collaborations
  • Publications

Muscle Opto-Biomechatronics

Group Leader

Michael Haug

Dr. Michael Haug, Akad. Rat a.Z.

Group Leader

Medical Biotechnology
Opto-Biomechatronics

Raum: Room 00.042-1
Paul-Gordan-Str. 3
91052 Erlangen
Germany
  • Telefon: +49913185-23175
  • Mobil: +491713599908
  • E-Mail: michael.haug@fau.de
  • Webseite: https://www.mbt.tf.fau.de
  • Instagram: Seite von Michael Haug

Research Topics

  • The MyoRobot
  • The TissueRegenerator
  • VR Augmented Learning

Services

  • Biomechanics Characterization of soft tissues

Muscle disorders are mainly characterized by a decline in force production and associated weakness, compromising mobility and quality of life in humans. The causes of inherited and acquired myopathies are diverse, as muscle force is the result of a complex activation cascade within the organ that comprises activation of ion channels, excitation-contraction coupling, calcium regulation and motor protein interaction. Additionally, muscle is not only characterized by its active but also by passive (visco-) elasticity components, and both set the biomechanical and structural properties of muscle tissue and cells. Studying those strucutral/biomechanical properties in health and disease is the medical science-related focus  of our research while engineering the opto-biomechatronics platforms to conveniently and automatically do so, is the fouces of our opto-mechano-electrical engineering R&D work. In this holistic approach, we strongly collaborate with clinicians and research institutes all over the world (e.g. US, Australia), providing us with input and up-to-date questions of modern medicine and biomaterial research.


https://www.mbt.tf.fau.de/files/2020/10/biomechanicsintro.mp4

To acquire the most reliable and repetitive information regarding the biomechanics properties of muscle across various morphometric scales, from whole muscle down to multicellular fiber bundle and single fiber preparations to identify specific mechanisms related to disease pathophysiology, clinical phenotyping or muscle performance during aging, we endeavour to design and engineer new devices that allow automated and standardized recordings in musculo-skeletal and heart muscle preparations to quantify  their broad spectrum of biomechanical and structural parameters. This task requires a broad knowledge of biological background, as well as engineering and biotechnology creativity, and sometimes, also a bit of nerdiness to select the state-of-the-art technology required to manufacture robotic systems and setup custom-made software to suite all needs. All design, and engineering implementation is performed in our in-house optics/mechanics/electronics workshops and CAD design studios (using Inventor software). Recent biomedical applications include full analyses of muscle mechanics in an animal model of human R350P desminopathy over a wide age range (Neuropathology Erlangen), alpha-actinin-3 deficiency (‚gene-of-speed‘) models (University of Melbourne, UNSW Sydney), dystrophic mdx mouse models (Cardiology Department Heidelberg),  cardiac wall stiffening in myocardial infarction (Pediatrics Cardiology Erlangen), myotome segmental elasticity during tadpole development (Developmental Biology Erlangen), and more ongoing work.

Friedrich-Alexander-Universität
Erlangen-Nürnberg

Schlossplatz 4
91054 Erlangen
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