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Publications

  1. Fey C, Betz J, Rosenbaum C, Kralisch D, Vielreicher M, Friedrich O, Zdzieblo D, Metzger M (2020) Bacterial nanocellulose as novel carrier for intestinal epithelial cells in drug delivery studies. Mat Sci Eng C. 109:110613. doi: 10.1016/j.msec.2019.110613

  1. Kahl M, Lesko C, Friedrich O, Gilbert DF (2019) 3D-Biodrucker für 150 Euro. Laborjournal 2019/11:64-65. https://www.laborjournal.de/epaper/LJ_19_11.pdf
  2. Schmitt MA, Friedrich O, Gilbert DF (2019) Der Portoporator. Laborjournal 2019/12:56.  https://www.laborjournal.de/epaper/LJ_19_12.pdf
  3. Steinmann S, Muenzner J, Ndreshkjana B, Geppert C, Eckstein M, Carle B, Bramsen J, Gasparini P, Friedrich O, Andersen C, Wang S, Eyuepoglu I, Baeuerle T, Hartmann A, Hampel C, Kemenes S, Schneider-Stock (2019) DAPK1 loss gene signature triggers tumor invasion and tumor cell-ECM interaction in colorectal tumor cells. Cell Death Dis. 10(12), 895. doi: 10.1038/s41419-019-2122-z
  4. Simon N, Sperber C, Voigtländer C, Born J, Gilbert DF, Seyferth S, Lee G, Kappes B, Friedrich O (2019) Improved stability of polyclonal antibodies: a case study with lyophilization‐conserved antibodies raised against epitopes from the malaria parasite Plasmodium falciparum. Eur J Pharm Sci. 142:105086. doi: 10.1016/j.ejps.2019.105086
  5. Kreiß L, Hohmann M, Klämpfl F, Schürmann S, Dehghani F, Schmidt M, Friedrich O, Büchler L (2019) Diffuse reflectance spectroscopy and Raman spectroscopy for label-free molecular characterization and automated detection of human cartilage and subchondral bone. Sensor Actuat B-Chem. 301:127121. doi: 10.1016/j.snb.2019.127121
  6. Aschenbrenner D, Friedrich O, Gilbert DF (2019) 3D-printed lab-on-a-chip platform for chemical stimulation and parallel analysis of ion channel function. Micromachines. 10:00548. doi:10.3390/mi10080548
  7. Kahl M, Gertig M, Hoyer P, Friedrich O, Gilbert DF (2019) Ultra-low-cost 3D bioprinting: Modification & application of an off-the-shelf desktop 3D-printer for biofabrication. Front Bioeng Biotechnol. 7:184. doi.org/10.3389/fbioe.2019.00184
  8. Capci A, Lorion MM, Wang H, Simon N, Leidenberger M, Borges Silva MC, Moreira DRM, Zhu Y, Meng Y, Chen JY, Lee YM, Friedrich O, Kappes B, Wang J, Ackermann L, Tsogoeva SB (2019) Artemisinin-(Iso)Quinoline Hybrids by C-H Activation and Click Chemistry: Combating Multidrug-Resistant Malaria. Angew Chem Int Edit. 58:13066-1307. doi: 10.1002/ange.201907224
  9. Lopez-Posadas R, Fastancz P, Martinez-Sanchez L del C, Panteleev-Ivlev J, Thonn V, Kisseleva T, Becker LS, Schulz-Kuhnt A, Zundler S, Wirtz S, Atreya R, Carle B, Friedrich O, Schürmann S, Waldner MJ, Neufert C, Brakebusch CH, Bergö MO, Neurath MF, Atreya I (2019) Inhibiting PGGT1B disrupts function of RHOA, resulting in T-cell expression of integrin α4β7 and development of colitis in mice. Gastroeneterology. 157:1293–1309. doi: 10.1053/j.gastro.2019.07.007
  10. Haug M, Meyer C, Reischl B, Pröß, G, Vetter K, Iberl J, Nübler S, Schürmann S, Rupitsch SJ, Heckel M, Pöschel T, Winter L, Herrmann H, Clemen CS, Schröder R, Friedrich O (2019) The MyoRobot technology discloses a premature biomechanical decay of skeletal muscle fiber bundles derived from R349P desminopathy mice. Sci Rep. 9:10769. doi: 10.1038/s41598-019-46723-6
  11. Friedrich O, Haug M, Reischl B, Prölß G, Kiriaev L, Head SI, Reid MB (2019) Single muscle fibre biomechanics and biomechatronics – the challenges, the pitfalls and the future. Int J Biochem Cell Biol. 114:105563. doi: 10.1016/j.biocel.2019.105563
  12. Haug M, Meyer C, Reischl B, Prölß G, Nübler S, Schürmann S, Schneidereit D, Heckel M, Pöschel T, Rupitsch SJ, Friedrich O (2019) MyoRobot 2.0: an advanced biomechatronics platform for automated, environmentally controlled skeletal muscle single fiber biomechanics assessment employing inbuilt real‐time optical imaging. Biosens Bioelectron. 138:111284. doi.org/10.1016/j.bios.2019.04.052
  13. Friedrich O, Merten AL, Schneidereit D, Guo Y, Schürmann S, Martinac B (2019) Stretch in Focus: 2D in-planar cell stretch systems for studies of cardiac mechano-signaling. Front Bioeng Biotechnol. 7:55. doi: 10.3389/fbioe.2019.00055
  14. Schmitt M, Friedrich O, Gilbert DF (2019) Portoporator©: A portable low-cost electroporation device for gene transfer to cultured cells in biomedical research, biotechnology and education. Biosens Bioelectron. 131:95-103. doi: 10.1016/j.bios.2019.02.024
  15. Pöttler M, Fliedner A, Bergmann J, Bui LK, Mühlberger M, Braun C, Graw M, Janko C, Friedrich O, Alexious C, Lyer S (2019) Magnetic tissue engineering of the vocal fold: generation of 3D cell-constructs using superparamagnetic iron oxide nanoparticles. Tissue Eng., in press. doi: 10.1089/ten.TEA.2019.0009
  16. Li JJ, Dunstan CR, Entezari A, Li Q, Steck R, Saifzadeh S, sandehpour A, Field JR, Akey A, Vielreicher M, Friedrich O, Roohani-Estefani SI, Zreiqat H (2019) A novel bone substitute with high bioactivity, strength and porosity for repairing large and load-bearing defects. Adv Healthcare Mater. 8(8):e1801298. doi: 10.1002/adhm.201801298
  17. Dilipkumar A, Al-Shemmary A, Kreiß, Cvecek C, Carle, Knieling F, Gonzales Menzes J, Thoma OM, Schmidt M, Neurath MF, Waldner M, Friedrich O, Schürmann S (2019) Label-free multiphoton endomicroscopy for minimally invasive in vivo imaging. Adv Sci. 6:801735. doi: 10.1002/advs.201801735
  18. Latronico N, Friedrich O (2019) Electrophysiological investigations of peripheral nerves and muscles: A method for looking at cell dysfunction in the critically ill patients. Crit Care. 23:33. doi: 10.1186/s13054-019-2331-y
  19. Karagöz AC, Leidenberger M, Hahn F, Friedrich O, Hampel F, Marschall M, Kappes B, Tsogoeva S (2019) Synthesis of new betulinic acid/betulin-derived dimers and Hybrids with potent antimalarial and antiviral activities. Bioorg Med Chem. 27:110-115.  doi: 10.1016/j.bmc.2018.11.018
  20. Gilbert DF, Abolpour Mofrad S, , Friedrich O, Wiest J (2018) Proliferation characteristics of cells cultured under periodic vs. static conditions. Cytotechnology. 71(1):443-452. doi: 10.1007/s10616-018-0263-z
  21. Schneidereit D, Schürmann S, Friedrich O (2019) PiezoGRIN: A high-pressure chamber incorporating GRIN lenses for high-resolution 3D-microscopy of living cells and tissues. Adv Sci. 6(4):180453. doi: 10.1002/advs.201801453
  22. Scheibe K, Kersten C, Schmied A, Vieth M, Primbs T, Carle B, Knieling F, Claussen J, Klimowicz AC, Zheng J, Baum P, Meyer S, Schürmann S, Friedrich O, Waldner MJ, Rath T, Wirtz S, Kollias G, Ekici AB, Atreya R, Raymond EL, Mbow ML, Neurath MF, Neufert C (2018) Inhibiting Interleukin 36 Receptor Signaling Reduces Fibrosis in Mice with Chronic Intestinal Inflammation. Gastroenterology. 156:1082-1097. doi: 10.1053/j.gastro.2018.11.029

  1. Fröhlich T, Kiss A, Wolfling J, Mernyak E, Kulmany A, Minorics R, Zupko I, Leidenberger M, Friedrich O, Kappes B, Hahn F, Marschall M, Schneider G, Tsogoeva S (2018) Synthesis of artemisinin‐estrogen hybrids highly active against HCMV, P. falciparum, cervical and breast cancer. ACS Med Chem Lett. 9:1128-1133. doi: 10.1021/acsmedchemlett.8b00381
  2. Schneidereit D, Nübler S, Prölß G, Reischl B, Schürmann S, Müller OJ, Friedrich O (2018) Optical prediction of single muscle fibre force production using a combined biomechatronics-Second Harmonic Generation Imaging Approach. Light Sci Appl. 7:79. doi: 10.1038/s41377-018-0080-3
  3. Ugele M, Weniger M, Stanzel M, Bassler M, Krause S, Friedrich O, Hayden O, Richter L (2018) Label-free high-throughput leukemia detection by holographic microscopy. Adv Sci. 5(12):1800761. doi: 10.1002/advs.201800761
  4. Reiling SJ, Krohne G, Friedrich O, Geary T, Rohrbach P (2018) Chloroquine exposure triggers distinct cellular responses in sensitive versus resistant Plasmodium falciparum parasites. Sci Rep. 8(1):11137.  doi: 10.1038/s41598-018-29422-6
  5. Vielreicher M, Kralisch D, Völkl S, Sternal F, Arkudas A, Friedrich O (2018) Bacterial nanocellulose stimulates mesenchymal stem cell expansion and formation of stable collagen-I networks as a novel biomaterial in tissue engineering. Sci Rep. 8:9401. doi:10.1038/s41598-018-27760-z
  6. Ugele M, Weniger M, Leidenberger M, Huang Y, Bassler M, Friedrich O, Kappes B, Hayden O (2018) Label-free, high-throughput detection of P. falciparum infection in sphered erythrocytes with digital holographic microscopy. Lab Chip. 18:1704-1712. doi:10.1039/c8lc00350e
  7. Karagöz AC, Reiter C, Seo EJ, Gruber L, Hahn F, Leidenberger M, Klein V, Hampel F, Friedrich O, Marschall M, Kappes B, Efferth T, Tsogoeva SB (2018) Access to new highly potent antileukemia, antiviral and antimalarial agents via hybridization of natural products (homo)egonol, thymoquinone and artemisinin. Bioorg Med Chem. 26:3610-3618. doi:10.1016/j.bmc.2018.05.041
  8. Li JJ, Akey A, Dunstan C, Vielreicher M, Friedrich O, Bell D, Zreiqat H (2018) Effects of material-tissue interactions on bone regeneration outcomes using baghdadite implants in a large animal model. Adv Healthcare Mater. e1800218. doi: 10.1002/adhm.201800218
  9. Scharin-Mehlmann , Häring A, Rommel M, Dirnecker T, Friedrich O, Frey L, Gilbert DF (2018) Nano- and micro-patterned S-, H- and X-PDMS for cell-based applications: Comparison of wettability, roughness and cell-derived parameters. Front Bioeng Biotechnol. 6:51. doi: 10.3389/fbioe.2018.00051
  10. Milanos S, Kuenzel K, Gilbert DF, Janzen D, Sasi M, Buettner A, Frimurer TM, Villmann C (2018) Structural changes at the myrtenol backbone reverse its positive allosteric potential into inhibitory GABAA receptor modulation. Biol Chem.  doi: 10.1515/hsz-2017-0262. PubMed PMID: 29408795.
  11. Schneidereit D, Tschernich J, Friedrich O, Scharin-Mehlmann M, Gilbert DF (2018) 3D printed reusable cell culture chamber with integrated electrodes for electrical stimulation and parallel microscopic evaluation. 3D Print Addit Manuf. 5(2):115-125. doi: 10.1089/3dp.2017.0103
  12. Fröhlich T, Hahn F, Belmudes L, Leidenberger M, Friedrich O, Kappes B, Couté Y, Marschall M, Tsogoeva SB (2018) Synthesis of artemisinin-derived di/tri-mers and dendrimers, investigation of their activity against P. falciparum and cytomegalovirus, and insights into their mechanisms of action. Chem Eur J. 24:8103-8113. doi: 10.1002/chem.201800729
  13. Reisbeck M, Richter L, Helou MJ, Arlinghaus S, Anton B, van Dommelen I, Nitzsche M , Baßler M, Kappes B, Friedrich O, Hayden O (2018) Hybrid integration of scalable mechanical and magnetophoretic focusing for magnetic flow cytometry. Biosens Bioelectron. 109:98-108. doi:10.1016/j.bios.2018.02.046
  14. Simon N, Friedrich O, Kappes B (2018) Quantification of human complement factor H binding to asexual malaria blood stages by an enzyme-linked immunosorbent assay. Vaccine. 36:1545-1547. doi: 10.1111/apha.12885
  15. Friedrich O, Diermeier S, Larsson L (2018) Weak by the Machines: Muscle Motor Protein Dysfunction – a side Effect of Intensive Care Unit Treatment. Acta Physiologica. 222:1-14. doi: 10.1016/j.vaccine.2018.01.080
  16. Fröhlich R, Reiter C, Saeed M, Hutterer C, Hahn F, Leidenberger M, Friedrich O, Kappes B, Marschall M, Efferth T, Tsogoeva S (2018) Synthesis of Thymoquinone-Artemisinin hybrids: new potent antileukemia , antiviral and antimalarial agents. ACS Med Chem Lett. 9(6):534-539. dx.doi.org/10.1021/acsmedchemlett.7b00412.
  17. Haug M, Reischl B, Prölß G, Pollmann C, Buckert T, Keidel C, Schürmann S, Hock M, Rupitsch S, Heckel M, Pöschel T, Scheibel T, Haynl C, Kiriaev L, Head SI, Friedrich O (2018) The MyoRobot: a novel automated biomechatronics syxstem to assess voltage/Ca2+ biosensors and active/passive biomechanics in muscle and biomaterials. Biosens Bioelectron. 102:589-599. doi: 10.1016/j.bios.2017.12.003
  18. Kravic B, Harbauer AB, Romanello V, Simeone L, Vögtle FN, Kaiser T, Straubinger M, Huraskin D, Böttcher M, Cerqua C, Martin ED, Poveda-Huertes D, Buttgereit A, Rabalski AJ, Heuss D, Rudolf R, Friedrich O, Litchfield D, Marber M, Salviati L, Mougiakakos D, Neuhuber W, Sandri M, Meisinger C, Hashemolhosseini S (2017) In mammalian skeletal muscle, phosphorylation of TOMM22 by protein kinase CSNK2/CK2 controls mitophagy. Autophagy. 14(2):311-335. doi: 10.1080/15548627.2017.1403716

  1. Taeger CD, Friedrich O, Horch RE, Drechsler C, Weigand A, Hopf F, Geppert CI, Münch F, Birkholz T, Wenzel C, Geis S, Prantl L, Buchholz R, Präbst K (2017). Extracorporeal perfusion – reduced to a one-way infusion. Clin Hemorheol Microcirc., in press. doi: 10.3233/CH-170298
  2. Resheq YJ, Menzner AK, Bosch J, Tickle J, Li KK, Wilhelm A, Hepburn E, Murihead G, Curbishley SM, Zimmermann HW, Bruns T, Gilbert DF, Mackensean A,  Weston CJ, Adams DH (2017). Impaired Transmigration of Myeloid-derived Suppressor Cells across Human Sinusoidal Endothelium is associated with Decreased Expression of CD13. J Immunol.ji1600466. doi: 10.4049/jimmunol.1600466
  3. Friedrich O, Schneidereit D, Nikolaev YA, Nikolova-Krstevski V, Schürmann S, Wirth-Hücking A, Merten AL, Fatkin D, Martinac B (2017) Adding Dimension to cellular mechanotransduction: Advances in biomedical engineeringof multiaxial cell-stretch systems and their application to cardiovascular biomechanics and mechano-signaling. Prog Biophy Mol Biol., in press.
  4. Diermeier S, Buttgereit A, Schürmann S, Winter L, Xu H, Murphy RM, Clemen CS, Schröder R, Friedrich O (2017) Pre-aged remodelling of myofibrillar architecture in skeletal muscle expressing R349P mutant desmin. Neurobiol Aging. 58:77-87. doi: 10.1016/j.neurobiolaging.2017.06.001
  5. Nikolova-Krstevski V, Wagner S, Yan Yu Y, Cox CD, Cvetkovska J, Hill AP, Huttner IG, Benson V, Werdich A, MacRae C, Feneley MP, Friedrich O, Martinac B, Fatkin D (2017) Endocardial TRPC6 channels act as atrial mechanosensors and load-dependent modulators of endocardial/myocardial cross-talk. JACC Basic Transl Sci. 2(5):575-590. doi: 10.1016/j.jacbts.2017.05
  6. Vielreicher M, Friedrich O (2017) Assessment of Population and ECM Production Using Multiphoton Microscopy as an Indicator of Cell Viability. Methods Mol Biol. 1601:243-255. doi: 10.1007/978-1-4939-6960-9_19
  7. Buttgereit A (2017) Second Harmonic Generation Microscopy of Muscle Cell Morphology and Dynamics. Methods Mol Biol. 1601:229-241. doi: 10.1007/978-1-4939-6960-9_18
  8. Friedrich O, Head SI (2017) Quantitative Ratiometric Ca2+ Imaging to Assess Cell Viablity. Methods Mol Biol. 1601:171-193. doi: 10.1007/978-1-4939-6960-9_14
  9. Gilbert DF (2017) Maßgeschneiderte Methoden und Technologien für high content imaging, Wissenschaft Special: High Content Imaging Methoden der Bildgebung. Biospektrum. 23:286. doi:10.1007/s12268-017-0798-0
  10. Gilbert DF, Friedrich O (Editors). Cell Viability Assays, Methods and Protocols. Methods Mol Biol. Methods in Springer New York, 2017, doi: 10.1007/978-1-4939-6960-9, ISBNs 978-1-4939-6959-3, 978-1-4939-6960-9
  11. Kuenzel K, Mofrad SA, Gilbert DF (2017) Phenotyping Cellular Viability by Functional Analysis of Ion Channels: GlyR-Targeted Screening in NT2-N Cells. Methods Mol Biol. 1601:205-214. doi: 10.1007/978-1-4939-6960-9_16
  12. Menzner AK, Gilbert DF (2017) A Protocol for In Vitro High-Throughput Chemical Susceptibility Screening in Differentiating NT2 Stem Cells.Methods Mol Biol. 1601:61-70. doi: 10.1007/978-1-4939-6960-9_5
  13. Fröhlich T, Reiter C, Ibrahim M, Beutel J, Hutterer C,  Zeitträger I, Bahsi H, Leidenberger M, Friedrich O, Kappes B, Efferth T, Marschall M, Tsogoeva S (2017) Synthesis of Novel Hybrids of Quinazoline and Artemisinin with High Activities Against Plasmodium falciparum, Human Cytomegalovirus and Leukemia Cells. ACS Omega. 2(6):2422-2431. doi: 10.1021/acsomega.7b00310.
  14. Schneidereit D, Gilbert DF (2017) Positioniertisch im Eigenbau. Laborjournal. 2017/4:62-64. Link zum Artikel
  15. Friedrich O, Diermeier S, Larsson L (2017) Weak by the Machines: Muscle Motor Protein Dysfunction – a side Effect of Intensive Care Unit Treatment. Acta Physiologica., in press. doi: 10.1111/apha.12885
  16. Diermeier S, Iberl J, Vetter K, Haug M, Pollmann, Reischl B, Buttgereit A, Schürmann S, Spörrer M, Goldmann WH, Fabry B, Elhamine F, Stehle R, Pfitzer G, Winter L, Clemen CS, Herrmann H, Schröder R, Friedrich O (2017) Early signs of architectural and biomechanical failure in isolated myofibers and immortalized myoblasts from desmin-mutant knock-in mice. Sci Rep. 7:1391. doi: 10.1038/s41598-017-01485-x
  17. Abolpour Mofrad S, Kuenzel K, Friedrich O, Gilbert DF (2017) On the generation of efficient methodologies for cell-based toxicity screening by
    comparative protocol analysis and optimization.     Single Cell Biology. 6:157. doi:10.4172/2168-9431.1000157
  18. Bock M, Parameshwarappa G, Bauer W, Hutterer C, Leidenberger M, Friedrich O, Marschall M, Kappes B, Tsogoeva S (2017) Deeper insight into the six-step domino reaction of aldehyde with maloninitrile and evaluation of antiviral and antimalarial activities of highly functionalized domino products. Chemistry Open. 6:364-374. doi:10.1002/open.201700005
  19. Larsson L, Friedrich O (2016) Critical illness myopathy (CIM) and ventilator-induced diaphragm muscle dysfunction (VIDD): acquired myopathies affecting contractile proteins. Compr Physiol. 7:105-112. doi: 10.1002/cphy.c150054
  20. Schneidereit D, Kraus L, Meier J, Friedrich O, Gilbert DF (2016) Step-by-step guide to building an inexpensive 3D printed motorized positioning stage for automated high-content screening microscopy. Biosensors Bioelectron. 92:472-481. doi: 10.1016/j.bios.2016.10.078

  1. Gilbert DF, Stebbing MJ, Kuenzel K, Murphy R, Zacharewicz E, Buttgereit A, Stokes L, Adams DJ, Friedrich O (2016) Store-operated Ca2+ entry (SOCE) and purinergic receptor-mediated Ca2+ homeostasis in murine BV2 microglia cells: early cellular responses to ATP-mediated microglia activation. Front Mol Neurosci. 9:111. doi: 10.3389/fnmol.2016.00111
  2. Schneidereit D, Vass H, Reischl B, Allen RJ, Friedrich O (2016) Calcium sensitive fluorescent dyes Fluo-4 and Fura Red under pressure: behaviour of fluorescence and buffer properties under hydrostatic pressures up to 200 MPa. PLoS One. 11(10):e1604509. doi: 10.1371/journal.pone.0164509
  3. Vielreicher M, Friedrich O (2016) Nichtinvasive Hochleistungstechnik zur Gewebeuntersuchung. Multiphotonen-Mikroskopie stellt Kollagen-I-Netzwerk in Knochen dar. Orthopädie & Rheuma. 19(5):38-43. doi: 10.1007/s15002-016-0984-3
  4. Olah T, Bodnar D, Toth A, Vincze J, Fodor J, Reischl B, Kovacs A, Ruzsnavsky O, Dienes B, Szentesi P, Friedrich O, Csernoch L (2016) Cannabinoid signalling inhibits sarcoplasmic Ca2+ release and regulates excitation-contraction coupling in mammalian skeletal muscle. J Physiol. 594.24:7381-7398. doi: 10.1113/JP272449
  5. Gilbert DF, Boutros M (2016) A Protocol for a High-Throughput Multiplex Cell Viability Assay. Methods Mol Biol. 1470:75-84. doi: 10.1007/978-1-4939-6337-9_6
  6. Reisbeck M, Helou MJ, Richter L, Kappes B, Friedrich O, Hayden O (2016) Magnetic fingerprints of rolling cells for quantitative flow cytometry in whole blood. Sci Rep. 6:32838. doi: 10.1038/srep32838
  7. Abolpour Mofrad S, Kuenzel K, Friedrich O, Gilbert DF (2016) Optimizing neuronal differentiation of human pluripotent NT2 stem cells in monolayer cultures. Dev Growth Differ. 58(8):664-676. doi: 10.1111/dgd.12323
  8. Spitzer P, Condic Mateja, Herrmann M, Oberstein TJ, Scharin-Mehlmann M, Gilbert DF, Friedrich O, Grömer T, Kornhuber J, Lang R, Maler JM (2016) Amyloidogenic amyloid ß-peptide variantes induce microglial agglutination and exert antimicrobial activity. Sci Rep. 6:32228. doi: 10.1038/srep32228
  9. Chernavskaia O, Heuke S, Vieht M, Friedrich O, Schürmann S, Atreya R, Stallmach A, Neurath MF, Waldner M, Petersen I, Schmitt M, Bocklitz T, Popp J (2016) Beyond endoscopic assessment in inflammatory bowel disease: real-time histology of disease activity by non-linear multimodal imaging. Sci Rep. 6:29239. doi: 10.1038/srep29239
  10. Künzel K, Friedrich O, Gilbert DF (2016) A recombinant human pluripotent stem cell line stably expressing halide-sensitive YFP-I152L for GABAAR and GlyR-targeted high-throughput drug screening and toxicity testing.  Front Mol Neurosci. 9:51. doi: 10.3389/fnmol.2016.00051
  11. Dakhil H, Gilbert DF, Malhotra D, Limmer A, Engelhardt H, Amtmann A, Hansmann J, Hübner H, Buchholz R, Friedrich O, Wierschem A (2016) Measuring average rheological quantities of cell monolayers in the linear viscoelastic regime. Rheol Acta. 55:527-536. doi: 10.1007/s00397-016-0936-5
  12. Schürmann S, Wagner S, Herlitze S, Fischer C, Gumbrecht S, Wirth-Hücking A, Prölß G, Lautscham LA, Fabry B, Goldmann WH, Nikolova-Krstevski V, Martinac B, Friedrich O (2016) The IsoStretcher: An isotropic cell stretch device to study mechanical biosensor pathways in living cells. Biosensors Bioelectron. 81:363-372. doi: 10.1016/j.bios.2016.03.015
  13. Taeger CD, Friedrich O, Drechsler C, Weigand A, Hobe F, Geppert CI, Münch F, Birkholz T, Buchholz R, Horch RE, Präbst K (2016) Hyrdoexyethyl starch solution for extracorporeal tissue perfusion. Clin Hemorheol Microcirc. 64:91-103. doi: 10.3233/CH-162049

  1. Wrosch JK, Volbers B, Gölitz P, Gilbert DF, Schwab S, Dörfler A, Kornhuber J (2015) Groemer TW. Feasibility and Diagnostic Accuracy of Ischemic Stroke Territory Recognition Based on Two-Dimensional Projections of Three-Dimensional Diffusion MRI Data. Front Neurol. 6:239. doi: 10.3389/fneur.2015.00239
  2. Menzner AK, Abolpur Mofrad S, Friedrich O, Gilbert DF (2015) Towards in vitro DT/DNT testing: assaying chemical susceptibility in early differentiating NT2 cells. Toxicology. 338:69-76. doi:10.1016/j.tox.2015.10.007
  3. Vielreicher M, Gellner M, Rottensteiner U, Horch R, Arkudas A, Friedrich O (2015) Multiphoton microscopy analysis of extracellular collagen-I network formation by mesenchymal stem cells. J Tissue Eng Regen Med. 10.1002. doi: 10.1002/term.2107
  4. Wagner S, Schürmann S, Hein S, Schüttler J, Friedrich O (2015) Septic cardiomyopathy in rat LPS-induced endotoxemia: relative contribution of cellular diastolic Ca2+ removal pathways, myofibrillar biomechanics properties and action of the cardiotonic drug levosimendan. Basic Res Cardiol. 110(5):507. doi: 10.1007/s00395-015-0507-4
  5. Auernheimer V, Lautscham LA, Leidenberger M, Friedrich O, Kappes B, Fabry B, Goldmann WH (2015) Vinculin phosphorylation at residues Y100 and Y1065 is required for cellular force transmission. J Cell Sci. 128(18):3435-3443. doi: 10.1242/jcs.172031
  6. Reiter C, Fröhlich T, Gruber L, Hutterer C, Marschall M, Voigtländer C, Friedrich O, Kappes B, Tsogoeva S (2015) Highly potent artemisinin derived dimers and trimers: synthesis and evaluation of their antimalaria, antileukemia and antiviral activities. Bioorg Med Chem. 23(17):5452-8. doi: 10.1016/j.bmc.2015.07.048
  7. Taeger CD, Friedrich O, Dragu A, Weigand A, Hobe F, Drechsler C, Geppert CI, Arkudas A, Münch F, Buchholz R, Pollmann C, Schramm A, Birkholz T, Horch RE, Präbst K (2015) Assessing viability of extracorporeal preserved muscle transplants using external field stimulation: a novel tool to improve methods prolonging bridge-to-transplantation time. Sci Rep. 5:11956. doi:10.1038/srep11956
  8. Friedrich O, Reid MB, Van den Berghe G, Vanhorebeek I, Hermanns G, Rich MM, Larsson L (2015) The sick and the weak: neuropathies/myopathies in the critically ill. Physiol Rev. 95:1025-1109. doi: 10.1152/physrev.00028.2014
  9. Ritterhoff J, Völkers M, Seitz A, Spaich K, Gao E, Peppel K, Pleger ST, Zimmermann WH, Friedrich O, Fink RH, Koch WJ, Katus HA, Most P (2015). S100A1 DNA-based inotropic therapy protects against pro-arrhythmogenic ryanodine receptor 2 dysfunction. Mol Ther. 23(8):1320-1330. doi: 10.1038/mt.2015.93
  10. Sinner B, Friedrich O, Lindner R, Bundscherer A, Graf BM (2015) Long-term NMDA receptor inhibition affects NMDA receptor expression and alters glutamatergic activity in developing rat hippocampal neurons. Toxicology. 333:147-155 doi: 10.1016/j.tox.2015.04.017
  11. Reiter C, Fröhlich T, Marschall M, Bahsi H, Leidenberger M, Friedrich O, Kappes B, Hampel F, Efferth T, Tsogoeva SB (2015) New efficient artemisinin derived agents against human leukemia cells, human cytomegalovirus and Plasmodium falciparum: 2nd generation 1,2,4-trioxane-ferrocene hybrids. Eur J Med Chem. 97:164-172. doi: 10.1016/j.ejmech.2015.04.053
  12. Head SI, Chan S, Houweling PJ, Quinlan KGR, Murphy R, Wagner S, Friedrich O, North KN (2015) Altered Ca2+ kinetics associated with α-actinin-3 deficiency may explain positive selection for ACTN3 null allele in human evolution. PLoS Genet. 11(2):e1004862. doi 10.1371/journal.pgen.1004862
  13. Clemen CS, Stöckigt F, Strucksberg KH, Chevessier F, Winter L, Schütz J, Bauer R, Thorweihe JM, Wenzel D, Schlötzer-Schrehardt U, Rasche V, Krsmanovic P, Katus HA, Rottbauer W, Just S, Müller OJ, Friedrich O, Meyer R, Herrmann H, Schrickel JW, Schröder R (2015) The toxic effect of R350P mutant desmin in striated muscle of man and mouse. Acta Neuropathol. 129(2):297-315. doi:10.1007/s00401-014-1363-2
  14. Walzik MP, Vollmar V, Lachnit T, Dietz H, Haug S, Bachmann H, Fath M, Aschenbrenner D, Abolpour Mofrad S, Friedrich O, Gilbert DF (2015) A portable low-cost long-term live-cell imaging platform for biomedical research and education. Biosens Bioelectron. 64:639-649. doi:10.1016/j.bios.2014.09.061

  1. Friedrich O, Reiling SJ, Wunderlich J, Rohrbach P (2014) Assessment of Plasmodium falciparum PfMDR1 transport rates using Fluo-4. J Cell Mol Med. 18(9):1851-1862. doi: 10.1111/jcmm.12313
  2. Buttgereit A, Weber C, Friedrich O (2014) A novel quantitative morphometry approach to assess regeneration in dystrophic skeletal muscle. Neuromuscul Disord. 24(7):596-603. doi: 10.1016/j.nmd.2014.04.011
  3. Friedrich O (2014) ‚Set the controls…‘ – phenotype matching beyond genetics in muscular dystrophy. Exp Physiol. 99(4):638-9. doi:10.1113/expphysiol.2014.077933
  4. Taskin S, Stumpf VI, Bachmann J, Weber C, Martignoni ME, Friedrich O (2014) Motor protein function in skeletal abdominal muscle of cachectic cancer patients. J Cell Mol Med. 18(1):69-79. doi: 10.1111/jcmm.12165
  5. Friedrich O, Yi B, Edwards JN, Reischl B, Wirth-Hücking A, Buttgereit A, Lang R, Weber C, Polyak F, Liu I, von Wegner F, Cully TR, Lee A, Most P, Völkers M (2014) Interleukin-1α Reversibly Inhibits Skeletal Muscle Ryanodine Receptor: A Novel Mechanism for Critical Illness Myopathy? Am J Respir Cell Mol Biol. 50(6):109-1106. doi: 10.1165/rcmb.2013-0059OC

  1. Lang NR, Münster S, Metzner C, Krauss P, Schürmann S, Lange J, Aifantis KE, Friedrich O, Fabry B (2013) Estimating the 3D Pore Size Distribution of Biopolymer Networks from Directionally Biased Data. Biophys J. 105(9):1967-1975. doi: 10.1016/j.bpj.2013.09.038
  2. Kuhns S, Schmidt KN, Reymann J, Gilbert DF, Neuner A, Hub B, Carvalho R, Wiedemann P, Zentgraf H, Erfle H, Klingmüller U, Boutros M, Pereira G (2013) The microtubule affinity regulating kinase MARK4 promotes axoneme extension during early ciliogenesis. J Cell Biol.200(4):505-522.
  3. Talwar S, Lynch JW, Gilbert DF (2013) Fluorescence-Based High-Throughput Functional Profiling of Ligand-Gated Ion Channels at the Level of Single Cells. PLoS ONE 8(3): e58479. doi:10.1371/journal.pone.0058479
  4. Buttgereit A, Weber C, Garbe CS, Friedrich O (2013) From chaos to split-ups–SHG microscopy reveals a specific remodelling mechanism in ageing dystrophic muscle. J Pathol.  Feb;229(3):477-85.
  5. Balansa W, Islam R, Gilbert DF, Fontaine F, Xiao X, Zhang H, Piggott AM, Lynch JW, Capon RJ (2013) Australian marine sponge alkaloids as a new class of glycine-gated chloride channel receptor modulator. Bioorg Med Chem. 2013 May 1. doi:pii: S0968-0896(13)00387-8. 10.1016/j.bmc.2013.04.061.
  6. Jung J, Weisenburger S, Albert S, Gilbert DF, Friedrich O, Eulenburg V, Kornhuber J, Groemer TW (2013) On the performance of scientific cameras with different sensor types in measuring dynamic processes in fluorescence microscopy. Microsc Res Tech. 76(8):835-843. doi: 10.1002/jemt.22236.
  7. Balansa W, Islam R, Fontaine F, Piggott AM, Zhang H, Xiao X, Webb TI, Gilbert DF, Lynch JW, Capon RJ (2013) Sesterterpene glycinyl-lactams: a new class of glycine receptor modulator from Australian marine sponges of the genus Psammocinia. Org Biomol Chem. PMID: 23760172.
  8. Vielreicher M, Schürmann S, Detsch R, Schmidt MA, Buttgereit A, Boccaccini A, Friedrich O (2013) Taking a deep look: modern microscopy technologies to optimize the design and functionality of biocompatible scaffolds for tissue engineering in regenerative medicine. J R Soc Interface. 10(86): 20130263 doi:10.1098/rsif.2013.0263
  9. Schürmann S, Foersch S, Atreya R, Neumann H, Friedrich O, Neurath MF,  Waldner MJ (2013) Label-Free Imaging of Inflammatory Bowel Disease Using Multiphoton Microscopy. Gastroenterology, 145(3):514-516. doi:10.1053/j.gastro.2013.06.054

  1. Garbe C, Buttgereit A, Schürmann S, Friedrich O (2012) Automated Multi-Scale Morphometry of Muscle Disease from Second-Harmonic Generation Microscopy using Tensor Based Image Processing.  IEEE Trans Biomed Eng. 59(1):39–44. doi:10.1109/TBME.2011.2167325
  2. Friedrich O, Wagner S, Battle AR, Schürmann S, Martinac B (2012) Mechano-regulation of the beating heart at the cellular level – Mechanosensitive channels in normal and diseased heart.  Prog Biophys Mol Biol. 110(2-3):226-238. doi:10.1016/j.pbiomolbio.2012.08.009
  3. Wagner S, Knipp S, Weber C, Hein S, Schinkel S, Walther A, Bekeredjian R, Müller OJ, Friedrich O (2012) The heart in Duchenne muscular dystrophy: early detection of contractile performance alteration. J Cell Mol Med. 16(12):3028-3036. doi: 10.1111/j.1582-4934.2012.01630.x.
  4. Cully T, Edwards JN, Friedrich O, Stephenson G, Murphy RM, Launikonis BS (2012) Changes in plasma membrane Ca-ATPase and stromal interacting molecule 1 expression levels for Ca(2+) signaling in dystrophic mdx mouse muscle. Am J Physiol Cell Physiol. 303(5):C567-C576. doi:10.1152/ajpcell.00144.2012

  1. Völkers M, Weidenhammer C, Herzog N, Qiu G, Spaich K, von Wegner F, Peppel K, Müller OJ, Schinkel S, Rabinowitz JE, Hippe HJ, Brinks H, Katus HA, Koch WJ, Eckhart AD, Friedrich O, Most P (2011) The inotropic peptide βARKct improves βAR responsiveness in normal and failing cardiomyocytes through G(βγ)-mediated L-type calcium current disinhibition. Circ Res. 108(1):27-39.
  2. Edwards JN, Blackmore DG, Gilbert DF, Murphy RM, Launikonis BS (2011) Store-operated calcium entry remains fully functional in aged mouse skeletal muscle despite a decline in STIM1 protein expression.Aging Cell. 10(4):675-685.
  3. Sinner B, Friedrich O, Zink W, Zausig Y, Graf BM (2011) The Toxic Effects of S(+)-Ketamine on Differentiating Neurons In Vitro as a Consequence of Suppressed Neuronal Ca2+ Oscillations. Anesth Analg. 113(5):1161-1169.
  4. Mohl MC, Iismaa SE, Xiao XH, Friedrich O, Wagner S, Nikolova-Krstevski V, Wu J, Yu ZY, Feneley M, Fatkin D, Allen DG, Graham RM (2011) Regulation of murine cardiac contractility by activation of {alpha}1A-adrenergic receptor-operated Ca2+ entry. Cardiovasc Res. 91(2):310-9.
  5. Sinner B, Friedrich O, Zausig Y, Bein T, Graf BM (2011) Toxic effects of midazolam on differentiating neurons in vitro as a consequence of suppressed neuronal Ca(2+)-oscillations. Toxicology. 290(1):96-101.
  6. Gilbert DF, Erdmann G, Zhang X, Fritsche A, Demir K, Jaedicke A, Muehlenberg K, Wanker EE, Boutros M (2011) A novel multiplex cell viability assay for high-throughput RNAi screening. PLoS One. 6(12): e28338. http://dx.doi.org/10.1371/journal.pone.0028338

  1. Schürmann S, von Wegner F, Fink RH, Friedrich O, Vogel M (2010) Second harmonic generation microscopy probes different states of motor protein interaction in myofibrils. Biophys J. 99(6):1842-1851.
  2. Friedrich O, Both M, Weber C, Schürmann S, Teichmann MDH, v Wegner F, Fink RHA, Vogel M, Chamberlain JS, Garbe C (2010) Microarchitecture is severely compromised but motor protein function is preserved in dystrophic mdx skeletal muscle. Biophys J. 98: 606-616.
  3. Derrer B, Windeisen V, Rodríguez GG, Seidler J, Gengenbacher M, Lehmann WD, Rippe K, Sinning I, Tews I, Kappes (2010) Defining the structural requirements for ribose 5-phosphate-binding and intersubunit cross-talk of the malarial pyridoxal 5-phosphate synthase. B.FEBS Lett. 584(19):4169-4174.
  4. Winter D, Seidler J, Kugelstadt D, Derrer B, Kappes B, Lehmann WD (2010) Minimally permutated peptide analogs as internal standards for relative and absolute quantification of peptides and proteins. Proteomics. 10(7):1510-1514.
  5. Friedrich O (2010) Pressure, the nervous system and ion channels: are humans too complicated? Undersea Hyperbar Med. 37(5):241-244.
  6. Edwards JN, Murphy RM, Cully TR, v Wegner F, Friedrich O, Launikonis BS (2010) Ultra-rapid activation and deactivation of store-operated Ca2+ entry in skeletal muscle. Cell Calcium. 47(5):458-467.
  7. Edwards JN, Friedrich O, Cully TR, v Wegner F, Murphy RM, Launikonis BS (2010) Upregulation of store-operated Ca2+ entry in dystrophic mdx mouse muscle.Am J Physiol Cell Physiol. 299(1):C42-C50
  8. Friedrich O (2010) One arm is enough, two might actually be worse.Exp Physiol. 95(5):607-608.
  9. Völkers M, Salz M, Herzog N, Frank D, Dolatabadi N, Frey N, Gude N, Friedrich O, Koch WJ, Katus HA, Sussman MA, Most P (2010) Orai1 and Stim1 regulates normal and hypertrophic growth in cardiomyocytes. J Mol Cell Cardiol. 48(6):1329-1334.
  10. Friedrich O, Fink RHA, von Wegner F (2010) New factors contributing to dynamic calcium regulation in the skeletal muscle triad – a crowded place. Biophys Rev. 2:29-38.
  11. Friedrich O, Hund E, von Wegner F (2010) Enhanced muscle shortening and impaired Ca(2+) channel function in an acute septic myopathy model.J Neurol. 257(4):546-555.
  12. Friedrich O (2010) Muscle function and high hydrostatic pressures. Cellular mechanisms and implications for taxonomic environmental locomotion. In: Comparative High Pressure Biology. P. Sebert (ed.), Science Publishers Inc., Enfield, USA, pp.211-249.
  13. Dueck J, Pikushchak E, Minkov L, Farghaly M, Neesse Th (2010) Mechanism of hydrocyclone separation with water injection.Minerals Engineering. 23:289–294.
  14. Hararah MA, Endres E, Dueck J, Minkov L, Neesse Th (2010) Flow conditions in the air core of the hydrocyclone.Minerals Engineering. 23:295–301.
  15. Gebhardt FM, Mitrovic AD, Gilbert DF, Vandenberg RJ, Lynch JW, Dodd PR (2010) Exon-skipping splice variants of excitatory amino acid transporter-2 (EAAT2) form heteromeric complexes with full-length EAAT2. J Biol Chem. 285(41):31313-24.
  16. Chung SK, Vanbellinghen JF, Mullins JG, Robinson A, Hantke J, Hammond CL, Gilbert DF, Freilinger M, Ryan M, Kruer MC, Masri A, Gurses C, Ferrie C, Harvey K, Shiang R, Christodoulou J, Andermann F, Andermann E, Thomas RH, Harvey RJ, Lynch JW, Rees MI (2010) Pathophysiological mechanisms of dominant and recessive GLRA1 mutations in hyperekplexia. J Neurosci. 30(28):9612-20.
  17. Balansa W, Islam R, Fontaine F, Piggott AM, Zhang H, Webb TI, Gilbert DF, Lynch JW, Capon RJ (2010) Ircinialactams: subunit-selective glycine receptor modulators from Australian sponges of the family Irciniidae. Med Chem. 18(8):2912-9.