Publications
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2022 2022
Gineste C. , Youhanna S. , Vorrink SU. , Henriksson S. , Hernández A. , Cheng AJ. , Chaillou T. , Buttgereit A. , Schneidereit D. , Friedrich O. , Hultenby K. , Bruton JD. , Ivarsson N. , Sandblad L. , Lauschke VM. , Westerblad H. :Enzymatically dissociated muscle fibers display rapid dedifferentiation and impaired mitochondrial calcium control iScience 25 2022 ), Art.Nr.: 105654 ISSN: 2589-0042 10.1016/j.isci.2022.105654 Haug M. , Reischl B. , Nübler S. , Kiriaev L. , Mázala DA. , Houweling PJ. , North KN. , Friedrich O. , Head SI. :Absence of the Z-disc protein α-actinin-3 impairs the mechanical stability of Actn3KO mouse fast-twitch muscle fibres without altering their contractile properties or twitch kinetics Skeletal Muscle 12 2022 ), Art.Nr.: 14 ISSN: 2044-5040 10.1186/s13395-022-00295-8 Haug M. , Ritter P. , Michael M. , Reischl B. , Schürmann S. , Prölß G. , Friedrich O. :Structure-Function Relationships in Muscle Fibres: MyoRobot Online Assessment of Muscle Fibre Elasticity and Sarcomere Length Distributions IEEE Transactions on Biomedical Engineering 69 2022 ), S. 148-155 ISSN: 0018-9294 10.1109/TBME.2021.3089739 Heiß R. , Tan L. , Schmidt S. , Regensburger A. , Ewert F. , Mammadova D. , Bühler A. , Vogel-Claussen J. , Voskrebenzev A. , Rauh M. , Rompel O. , Nagel AM. , Levy S. , Bickelhaupt S. , May M. , Uder M. , Metzler M. , Trollmann R. , Wölfle J. , Wagner A. , Knieling F. :Pulmonary Dysfunction after Pediatric COVID-19 Radiology 2022 )ISSN: 0033-8419 10.1148/radiol.221250 Kara A. , Distler T. , Polley C. , Schneidereit D. , Seitz H. , Friedrich O. , Tihminlioglu F. , Boccaccini AR. :3D printed gelatin/decellularized bone composite scaffolds for bone tissue engineering: Fabrication, characterization and cytocompatibility study Materials Today Bio 15 2022 )ISSN: 2590-0064 10.1016/j.mtbio.2022.100309 Kratzer S. , Arkudas A. , Himmler M. , Schubert DW. , Schneidereit D. , Bauer J. , Friedrich O. , Horch RE. , Cai A. :Vascularization of Poly-ε-Caprolactone-Collagen I-Nanofibers with or without Sacrificial Fibers in the Neurotized Arteriovenous Loop Model Cells 11 2022 ), S. 3774 ISSN: 2073-4409 10.3390/cells11233774 Kreiß L. , Ganzleben I. , Mühlberg A. , Ritter P. , Schneidereit D. , Becker C. , Neurath M. , Friedrich O. , Schürmann S. , Waldner M. :Label-free analysis of inflammatory tissue remodeling in murine lung tissue based on multiphoton microscopy, Raman spectroscopy and machine learning Journal of Biophotonics 2022 )ISSN: 1864-063X 10.1002/jbio.202200073 Kreiß L. , Thoma OM. , Lemire S. , Lechner K. , Carlé BE. , Dilipkumar A. , Kunert T. , Scheibe K. , Heichler C. , Merten AL. , Weigmann B. , Neufert C. , Hildner K. , Vieth M. , Neurath M. , Friedrich O. , Schürmann S. , Waldner M. :Label-Free Characterization and Quantification of Mucosal Inflammation in Common Murine Colitis Models With Multiphoton Imaging Inflammatory Bowel Diseases 2022 )ISSN: 1078-0998 10.1093/ibd/izac114 Kunze P. , Kreiß L. , Novosadová V. , Roehe AV. , Steinmann S. , Prochazka J. , Geppert C. , Hartmann A. , Schürmann S. , Friedrich O. , Schneider-Stock R. :Multiphoton Microscopy Reveals DAPK1‐Dependent Extracellular Matrix Remodeling in a Chorioallantoic Membrane (CAM) Model Cancers 14 2022 ), Art.Nr.: 2364 ISSN: 2072-6694 10.3390/cancers14102364 Lemire S. , Thoma OM. , Kreiß L. , Völkl S. , Friedrich O. , Neurath M. , Schürmann S. , Waldner M. :Natural NADH and FAD Autofluorescence as Label-Free Biomarkers for Discriminating Subtypes and Functional States of Immune Cells International Journal of Molecular Sciences 23 2022 ), Art.Nr.: 2338 ISSN: 1422-0067 10.3390/ijms23042338 Michael M. , Kovbasyuk L. , Ritter P. , Reid MB. , Friedrich O. , Haug M. :Redox Balance Differentially Affects Biomechanics in Permeabilized Single Muscle Fibres—Active and Passive Force Assessments with the Myorobot Cells 11 2022 ), Art.Nr.: 3715 ISSN: 2073-4409 10.3390/cells11233715 Müller-Seubert W. , Ostermaier P. , Horch RE. , Distel L. , Frey B. , Cai A. , Arkudas A. :Intra-and Early Postoperative Evaluation of Malperfused Areas in an Irradiated Random Pattern Skin Flap Model Using Indocyanine Green Angiography and Near-Infrared Reflectance-Based Imaging and Infrared Thermography Journal of Personalized Medicine 12 2022 ), Art.Nr.: 237 ISSN: 2075-4426 10.3390/jpm12020237 Ritter P. , Cai A. , Reischl B. , Fiedler M. , Prölß G. , Frie B. , Kretzschmar E. , Michael M. , Hartmann K. , Lesko C. , Salti H. , Arkudas A. , Horch RE. , Paulsen F. , Friedrich O. , Haug M. :MyoBio: An automated bioreactor system technology for standardized perfusion-decellularization of whole skeletal muscle IEEE transactions on bio-medical engineering 2022 )ISSN: 1558-2531 10.1109/TBME.2022.3142317 Ritter P. , Nübler S. , Buttgereit A. , Smith LR. , Mühlberg A. , Bauer J. , Michael M. , Kreiß L. , Haug M. , Barton E. , Friedrich O. :Myofibrillar Lattice Remodeling Is a Structural Cytoskeletal Predictor of Diaphragm Muscle Weakness in a Fibrotic mdx (mdx Cmah(-/-)) Model International Journal of Molecular Sciences 23 2022 )ISSN: 1422-0067 10.3390/ijms231810841 Ryma M. , Genc H. , Nadernezhad A. , Paulus I. , Schneidereit D. , Friedrich O. , Andelovic K. , Lyer S. , Alexiou C. , Cicha I. , Groll J. :A Print-and-Fuse Strategy for Sacrificial Filaments Enables Biomimetically Structured Perfusable Microvascular Networks with Functional Endothelium Inside 3D Hydrogels Advanced Materials 2022 )ISSN: 0935-9648 10.1002/adma.202200653 Schmalzl A. , Leupold T. , Kreiß L. , Waldner M. , Schürmann S. , Neurath M. , Becker C. , Wirtz S. :Interferon regulatory factor 1 (IRF-1) promotes intestinal group 3 innate lymphoid responses during Citrobacter rodentium infection Nature Communications 13 2022 ), Art.Nr.: 5730 ISSN: 2041-1723 10.1038/s41467-022-33326-5 Schmid R. , Schmidt S. , Detsch R. , Horder H. , Blunk T. , Schrüfer S. , Schubert DW. , Fischer L. , Thievessen I. , Heltmann-Meyer S. , Steiner D. , Schneidereit D. , Friedrich O. , Grüneboom A. , Amouei H. , Wajant H. , Horch RE. , Boßerhoff AK. , Arkudas A. , Kengelbach-Weigand A. :A new printable alginate / hyaluronic acid / gelatin hydrogel suitable for biofabrication of in vitro and in vivo metastatic melanoma models Advanced Functional Materials Volume 32 2022 )ISSN: 1616-301X 10.1002/adfm.202107993 Simon N. , Voigtländer C. , Kappes B. , Rohrbach P. , Friedrich O. :PfMDR1 Transport Rates Assessed in Intact Isolated Plasmodium falciparum Digestive Vacuoles Reflect Functional Drug Resistance Relationship with pfmdr1 Mutations Pharmaceuticals 15 2022 ), Art.Nr.: 202 ISSN: 1424-8247 10.3390/ph15020202 Xu S. , Yang X. , Liu W. , Jonsson J. , Qian R. , Konda PC. , Zhou KC. , Kreiß L. , Wang H. , Dai Q. , Berrocal E. , Horstmeyer R. :Imaging Dynamics Beneath Turbid Media via Parallelized Single-Photon Detection Advanced Science 2022 )ISSN: 2198-3844 10.1002/advs.202201885
2021 2021
Bojarski C. , Waldner M. , Rath T. , Schürmann S. , Neurath M. , Atreya R. , Siegmund B. :Innovative Diagnostic Endoscopy in Inflammatory Bowel Diseases: From High-Definition to Molecular Endoscopy Frontiers in Medicine 8 2021 ), Art.Nr.: 655404 ISSN: 2296-858X 10.3389/fmed.2021.655404 Dakhil H. , Basu SK. , Steiner S. , Gerlach Y. , Soller A. , Pan S. , Germann N. , Leidenberger M. , Kappes B. , Wierschem A. :Buffered λ-DNA solutions at high shear rates Journal of Rheology 65 2021 ), S. 159-169 ISSN: 0148-6055 10.1122/8.0000136 Distler T. , Kretzschmar L. , Schneidereit D. , Girardo S. , Goswami R. , Friedrich O. , Detsch R. , Guck J. , Boccaccini AR. , Budday S. :Mechanical properties of cell- and microgel bead-laden oxidized alginate-gelatin hydrogels Biomaterials Science 2021 ), Art.Nr.: d0bm02117b ISSN: 2047-4830 10.1039/D0BM02117B https://pubs.rsc.org/en/content/articlelanding/2021/bm/d0bm02117b Distler T. , Polley C. , Shi F. , Schneidereit D. , Ashton MD. , Friedrich O. , Kolb JF. , Hardy JG. , Detsch R. , Seitz H. , Boccaccini AR. :Electrically Conductive and 3D-Printable Oxidized Alginate-Gelatin Polypyrrole:PSS Hydrogels for Tissue Engineering Advanced Healthcare Materials 2021 )ISSN: 2192-2640 10.1002/adhm.202001876 Eggert S. , Kahl M. , Bock N. , Meinert C. , Friedrich O. , Hutmacher DW. :An open-source technology platform to increase reproducibility and enable high-throughput production of tailorable gelatin methacryloyl (GelMA) - based hydrogels Materials and Design 204 2021 ), Art.Nr.: 109619 ISSN: 0261-3069 10.1016/j.matdes.2021.109619 Gilbert D. , Friedrich O. , Lesko C. , Hartmann K. :Hilfsmittel und Verfahren für zellbasiertes high content imaging BioSpektrum 27 2021 ), S. 156-159 ISSN: 0947-0867 10.1007/s12268-021-1542-3 Goossens C. , Weckx R. , Derde S. , Van Helleputte L. , Schneidereit D. , Haug M. , Reischl B. , Friedrich O. , Van Den Bosch L. , Van Den Berghe G. , Langouche L. :Impact of prolonged sepsis on neural and muscular components of muscle contractions in a mouse model Journal of Cachexia, Sarcopenia and Muscle 2021 )ISSN: 2190-5991 10.1002/jcsm.12668 Guo Y. , Merten AL. , Schöler U. , Yu ZY. , Cvetkovska J. , Fatkin D. , Feneley MP. , Martinac B. , Friedrich O. :In vitro cell stretching technology (IsoStretcher) as an approach to unravel Piezo1-mediated cardiac mechanotransduction Progress in Biophysics & Molecular Biology 159 2021 ), S. 22-33 ISSN: 0079-6107 10.1016/j.pbiomolbio.2020.07.003 Heilmann M. , Breiter R. , Becker A. :Towards rare earth element recovery from wastewaters: biosorption using phototrophic organisms Applied Microbiology and Biotechnology 2021 )ISSN: 0175-7598 10.1007/s00253-021-11386-9 Heltmann-Meyer S. , Steiner D. , Mueller C. , Schneidereit D. , Friedrich O. , Salehi S. , Engel F. , Arkudas A. , Horch RE. :Gelatin methacryloyl is a slow degrading material allowing vascularization and long-term use in vivo Biomedical Materials 16 2021 )ISSN: 1748-6041 10.1088/1748-605X/ac1e9d Kah DT. , Winterl A. , Přechová M. , Schöler U. , Schneider W. , Friedrich O. , Gregor M. , Fabry B. :A low-cost uniaxial cell stretcher for six parallel wells HardwareX 9 2021 ), Art.Nr.: e00162 ISSN: 2468-0672 10.1016/j.ohx.2020.e00162 Kahl M. , Schneidereit D. , Bock N. , Friedrich O. , Hutmacher DW. , Meinert C. :MechAnalyze: An Algorithm for Standardization and Automation of Compression Test Analysis Tissue Engineering - Part C: Methods 27 2021 ), S. 529-542 ISSN: 1937-3392 10.1089/ten.tec.2021.0170 Martonová D. , Alkassar M. , Seufert J. , Holz D. , Duong MT. , Reischl B. , Friedrich O. , Leyendecker S. :Passive mechanical properties in healthy and infarcted rat left ventricle characterised via a mixture model Journal of the Mechanical Behavior of Biomedical Materials 119 2021 ), Art.Nr.: 104430 ISSN: 1751-6161 10.1016/j.jmbbm.2021.104430 Minkov L. , Dück J. , Hassan MMA. , Ali MAM. , Farghaly MG. :Optimizing the separation characteristics of the waterinjection hydrocyclone using mathematical modelling Mining of Mineral Deposits 15 2021 ), S. 114-121 ISSN: 2415-3435 10.33271/mining15.04.114 Schmid R. , Schmidt S. , Detsch R. , Horder H. , Blunk T. , Schrüfer S. , Schubert DW. , Fischer L. , Thievessen I. , Heltmann-Meyer S. , Steiner D. , Schneidereit D. , Friedrich O. , Grüneboom A. , Amouei H. , Wajant H. , Horch RE. , Boßerhoff AK. , Arkudas A. , Kengelbach-Weigand A. :A new printable alginate / hyaluronic acid / gelatin hydrogel suitable for biofabrication of in vitro and in vivo metastatic melanoma models Advanced Functional Materials 2021 )ISSN: 1616-301X 10.1002/adfm.202107993 https://onlinelibrary.wiley.com/doi/full/10.1002/adfm.202107993 Schmid R. , Schmidt S. , Detsch R. , Horder H. , Blunk T. , Schrüfer S. , Schubert DW. , Fischer L. , Thievessen I. , Heltmann-Meyer S. , Steiner D. , Schneidereit D. , Friedrich O. , Grüneboom A. , Amouei H. , Wajant H. , Horch RE. , Boßerhoff AK. , Arkudas A. , Kengelbach-Weigand A. :A New Printable Alginate/Hyaluronic Acid/Gelatin Hydrogel Suitable for Biofabrication of In Vitro and In Vivo Metastatic Melanoma Models Advanced Functional Materials 2021 )ISSN: 1616-301X 10.1002/adfm.202107993 Schneidereit D. , Broellochs A. , Ritter P. , Kreiß L. , Mokhtari Z. , Beilhack A. , Krönke G. , Ackermann J. , Faas M. , Grüneboom A. , Schürmann S. , Friedrich O. :An advanced optical clearing protocol allows label-free detection of tissue necrosis via multiphoton microscopy in injured whole muscle Theranostics 11 2021 ), S. 2876-2891 ISSN: 1838-7640 10.7150/thno.51558 Shafiee A. , Cavalcanti A. , Saidy NT. , Schneidereit D. , Friedrich O. , Ravichandran A. , De-Juan-Pardo EM. , Hutmacher DW. :Convergence of 3D printed biomimetic wound dressings and adult stem cell therapy. Biomaterials 268 2021 ), S. 120558 ISSN: 0142-9612 10.1016/j.biomaterials.2020.120558 Spörrer M. , Kah DT. , Gerum R. , Reischl B. , Huraskin D. , Dessalles CA. , Schneider W. , Goldmann W. , Herrmann H. , Thievessen I. , Clemen CS. , Friedrich O. , Hashemolhosseini S. , Schröder R. , Fabry B. :The desmin mutation R349P increases contractility and fragility of stem cell-generated muscle micro-tissues Neuropathology and Applied Neurobiology 2021 )ISSN: 0305-1846 10.1111/nan.12784 Vielreicher M. , Bozec A. , Schett G. , Friedrich O. :Murine Metatarsus Bone and Joint Collagen-I Fiber Morphologies and Networks Studied With SHG Multiphoton Imaging Frontiers in Bioengineering and Biotechnology 9 2021 ), Art.Nr.: 608383 ISSN: 2296-4185 10.3389/fbioe.2021.608383 Zimmermann T. , Gebhardt L. , Kreiß L. , Schneider C. , Arndt S. , Karrer S. , Friedrich O. , Fischer MJM. , Boßerhoff AK. :Acidified nitrite contributes to the antitumor effect of cold atmospheric plasma on melanoma cells International Journal of Molecular Sciences 22 2021 ), Art.Nr.: 3757 ISSN: 1422-0067 10.3390/ijms22073757
2020 2020
Carullo G. , Mazzotta S. , Koch AM. , Hartmann K. , Friedrich O. , Gilbert D. , Vega-Holm M. , Schneider-Stock R. , Aiello F. :New oleoyl hybrids of natural antioxidants: Synthesis and in vitro evaluation as inducers of apoptosis in colorectal cancer cells Antioxidants 9 2020 ), S. 1-16 ISSN: 2076-3921 10.3390/antiox9111077 Distler T. , Solisito A. , Schneidereit D. , Friedrich O. , Detsch R. , Boccaccini AR. :3D printed oxidized alginate-gelatin bioink provides guidance for C2C12 muscle precursor cell orientation and differentiation via shear stress during bioprinting Biofabrication 12 2020 ), Art.Nr.: ARTN 045005 ISSN: 1758-5082 10.1088/1758-5090/ab98e4 Fey C. , Betz J. , Rosenbaum C. , Kralisch D. , Vielreicher M. , Friedrich O. , Metzger M. , Zdzieblo D. :Bacterial nanocellulose as novel carrier for intestinal epithelial cells in drug delivery studies Materials Science and Engineering C 109 2020 ), Art.Nr.: 110613 ISSN: 0928-4931 10.1016/j.msec.2019.110613 Fröhlich T. , Mai C. , Bogautdinov RP. , Morozkina SN. , Shavva AG. , Friedrich O. , Gilbert D. , Tsogoeva S. :Synthesis of Tamoxifen-Artemisinin and Estrogen-Artemisinin Hybrids Highly Potent Against Breast and Prostate Cancer ChemMedChem 2020 )ISSN: 1860-7179 10.1002/cmdc.202000174 Hazur J. , Detsch R. , Karakaya E. , Kaschta J. , Teßmar J. , Schneidereit D. , Friedrich O. , Schubert DW. , Boccaccini AR. :Improving alginate printability for biofabrication: establishment of a universal and homogeneous pre-crosslinking technique Biofabrication 12 2020 ), Art.Nr.: 045004 ISSN: 1758-5082 10.1088/1758-5090/ab98e5 Juia T. , Horch RE. , Grüner J. , Schmid R. , Kengelbach-Weigand A. , Schubert DW. , Werner S. , Schneidereit D. , Friedrich O. , Ludolph I. :Size matters-in vitro behaviour of human fibroblasts on textured silicone surfaces with different pore sizes Journal of Materials Science: Materials in Medicine 2020 )ISSN: 0957-4530 10.1007/s10856-020-6360-5 https://link.springer.com/article/10.1007/s10856-020-6360-5 Kreiß L. , Thoma OM. , Dilipkumar A. , Carlé BE. , Longequeue P. , Kunert T. , Rath T. , Hildner K. , Neufert C. , Neurath M. , Friedrich O. , Schürmann S. , Waldner MJ. , Vieth M. :Label-Free In Vivo Histopathology of Experimental Colitis via 3-Channel Multiphoton Endomicroscopy Gastroenterology 2020 )ISSN: 0016-5085 10.1053/j.gastro.2020.05.081 No YJ. , Tarafder S. , Reischl B. , Ramaswamy Y. , Dunstan CR. , Friedrich O. , Lee CH. , Zreiqat H. :High-Strength Fiber-Reinforced Composite Hydrogel Scaffolds as Biosynthetic Tendon Graft Material ACS Biomaterials Science and Engineering 6 2020 ), S. 1887-1898 ISSN: 2373-9878 10.1021/acsbiomaterials.9b01716 Pollmann C. , Haug M. , Reischl B. , Prölß G. , Pöschel T. , Rupitsch S. , Clemen CS. , Schröder R. , Friedrich O. :Growing old too early: Skeletal muscle single fiber biomechanics in ageing r349p desmin knock-in mice using the myorobot technology International Journal of Molecular Sciences 21 2020 ), S. 1-18 ISSN: 1422-0067 10.3390/ijms21155501 Ritter P. , Bye LJ. , Finol-Urdaneta RK. , Lesko C. , Adams DJ. , Friedrich O. , Gilbert D. :A method for high-content functional imaging of intracellular calcium responses in gelatin-immobilized non-adherent cells Experimental Cell Research 395 2020 ), Art.Nr.: 112210 ISSN: 0014-4827 10.1016/j.yexcr.2020.112210 Schwappacher R. , Schink K. , Sologub S. , Dieterich W. , Reljic D. , Friedrich O. , Herrmann HJ. , Neurath M. , Zopf Y. :Physical activity and advanced cancer: evidence of exercise-sensitive genes regulating prostate cancer cell proliferation and apoptosis The Journal of Physiology 2020 )ISSN: 0022-3751 10.1113/JP279150 Simon N. , Sperber C. , Voigtländer C. , Born J. , Gilbert D. , Seyferth S. , Lee G. , Kappes B. , Friedrich O. :Improved stability of polyclonal antibodies: A case study with lyophilization-conserved antibodies raised against epitopes from the malaria parasite Plasmodium falciparum European Journal of Pharmaceutical Sciences 142 2020 ), Art.Nr.: 105086 ISSN: 0928-0987 10.1016/j.ejps.2019.105086 Taeger CD. , Friedrich O. , Horch RE. , Distler C. , Kengelbach-Weigand A. , Wenzel C. , Prantl L. , Präbst K. :Tissue Viability of Free Flaps after Extracorporeal Perfusion Using a Modified Hydroxyethyl Starch Solution Journal of Clinical Medicine 9 2020 )ISSN: 2077-0383 10.3390/jcm9123929 Weizel A. , Distler T. , Schneidereit D. , Friedrich O. , Bräuer L. , Paulsen F. , Detsch R. , Boccaccini AR. , Budday S. , Seitz H. :Complex mechanical behavior of human articular cartilage and hydrogels for cartilage repair Acta Biomaterialia 2020 )ISSN: 1742-7061 10.1016/j.actbio.2020.10.025 https://www.sciencedirect.com/science/article/pii/S1742706120306140
2019 2019
Aschenbrenner D. , Friedrich O. , Gilbert D. :3D printed lab-on-a-chip platform for chemical stimulation and parallel analysis of ion channel function Micromachines 10 2019 ), Art.Nr.: 548 ISSN: 2072-666X 10.3390/mi10080548 Capci Karagöz A. , Leidenberger M. , Hahn F. , Friedrich O. , Hampel F. , Marschall M. , Kappes B. , Tsogoeva S. :Synthesis of new betulinic acid/betulin-derived dimers and hybrids with potent antimalarial and antiviral activities Bioorganic & Medicinal Chemistry 27 2019 ), S. 110-115 ISSN: 0968-0896 10.1016/j.bmc.2018.11.018 Dilipkumar A. , Al-Shemmary A. , Kreiß L. , Cvecek K. , Carlé BE. , Knieling F. , Menezes JG. , Thoma OM. , Schmidt M. , Neurath M. , Waldner M. , Friedrich O. , Schürmann S. :Label-Free Multiphoton Endomicroscopy for Minimally Invasive In Vivo Imaging Advanced Science 6 2019 ), Art.Nr.: 1801735 ISSN: 2198-3844 10.1002/advs.201801735 Friedrich O. , Haug M. , Reischl B. , Prölß G. , Kiriaev L. , Head SI. , Reid MB. :Single muscle fibre biomechanics and biomechatronics – The challenges, the pitfalls and the future International Journal of Biochemistry and Cell Biology 114 2019 ), Art.Nr.: 105563 ISSN: 1357-2725 10.1016/j.biocel.2019.105563 Friedrich O. , Merten AL. , Schneidereit D. , Guo Y. , Schürmann S. , Martinac B. :Stretch in Focus: 2D Inplane Cell Stretch Systems for Studies of Cardiac Mechano-Signaling Frontiers in Bioengineering and Biotechnology 7 2019 )ISSN: 2296-4185 10.3389/fbioe.2019.00055 Gilbert D. , Abolpour Mofrad S. , Friedrich O. , Wiest J. :Proliferation characteristics of cells cultured under periodic versus static conditions. Cytotechnology 71 2019 ), S. 443-452 ISSN: 0920-9069 10.1007/s10616-018-0263-z Haug M. , Meyer C. , Reischl B. , Prölß G. , Nübler S. , Schürmann S. , Schneidereit D. , Heckel M. , Pöschel T. , Rupitsch S. , Friedrich O. :MyoRobot 2.0: An advanced biomechatronics platform for automated, environmentally controlled skeletal muscle single fiber biomechanics assessment employing inbuilt real-time optical imaging Biosensors and Bioelectronics 138 2019 ), Art.Nr.: 111284 ISSN: 0956-5663 10.1016/j.bios.2019.04.052 Haug M. , Meyer C. , Reischl B. , Prölß G. , Vetter K. , Iberl J. , Nübler S. , Schürmann S. , Rupitsch S. , Heckel M. , Pöschel T. , Winter L. , Herrmann H. , Clemen CS. , Schröder R. , Friedrich O. :The MyoRobot technology discloses a premature biomechanical decay of skeletal muscle fiber bundles derived from R349P desminopathy mice Scientific Reports 9 2019 ), Art.Nr.: 10769 ISSN: 2045-2322 10.1038/s41598-019-46723-6 Kahl M. , Gertig M. , Hoyer P. , Friedrich O. , Gilbert D. :Ultra-low-cost 3D bioprinting: Modification and application of an off-the-shelf desktop 3D-printer for biofabrication Frontiers in Bioengineering and Biotechnology 7 2019 ), Art.Nr.: 184 ISSN: 2296-4185 10.3389/fbioe.2019.00184 Kreiß L. , Hohmann M. , Klämpfl F. , Schürmann S. , Dehghani F. , Schmidt M. , Friedrich O. , Büchler L. :Diffuse reflectance spectroscopy and Raman spectroscopy for label-free molecular characterization and automated detection of human cartilage and subchondral bone Sensors and Actuators B-Chemical 301 2019 ), Art.Nr.: 127121 ISSN: 0925-4005 10.1016/j.snb.2019.127121 Latronico N. , Friedrich O. :Electrophysiological investigations of peripheral nerves and muscles: a method for looking at cell dysfunction in the critically ill patients Critical Care 23 2019 )ISSN: 1466-609X 10.1186/s13054-019-2331-y Li JJ. , Dunstan C. , Entezari A. , Li Q. , Steck R. , Saifzadeh S. , Sadeghpour A. , Field JR. , Akey A. , Vielreicher M. , Friedrich O. , Esfahani SI. , Zreiqat H. :A novel bone substitute with high bioactivity, strength, and porosity for repairing large and load-bearing bone defects Advanced Healthcare Materials 2019 ), Art.Nr.: e1801298 ISSN: 2192-2640 10.1002/adhm.201801298 Lopez Posadas R. , Fastancz P. , Martínez-Sánchez LdC. , Panteleev-Ivlev J. , Thonn V. , Kisseleva T. , Becker LS. , Schulz-Kuhnt A. , Zundler S. , Wirtz S. , Atreya R. , Carlé BE. , Friedrich O. , Schürmann S. , Waldner M. , Neufert C. , Brakebusch CH. , Bergö MO. , Neurath M. , Atreya I. :Inhibiting PGGT1B Disrupts Function of RHOA, Resulting in T-cell Expression of Integrin α4β7 and Development of Colitis in Mice Gastroenterology 157 2019 ), S. 1293-1309 ISSN: 0016-5085 10.1053/j.gastro.2019.07.007 Muthumbi AK. , Chaware A. , Kim K. , Zhou KC. , Konda PC. , Chen RY. , Judkewitz B. , Erdmann A. , Kappes B. , Horstmeyer R. :Learned sensing: jointly optimized microscope hardware for accurate image classification Biomedical Optics Express 10 2019 ), S. 6351-6369 ISSN: 2156-7085 10.1364/BOE.10.006351 Poettler M. , Fliedner A. , Bergmann J. , Bui LK. , Mühlberger M. , Braun C. , Graw M. , Janko C. , Friedrich O. , Alexiou C. , Lyer S. :Magnetic Tissue Engineering of the Vocal Fold Using Superparamagnetic Iron Oxide Nanoparticles Tissue Engineering: Parts A, B, and C 2019 )ISSN: 1937-3368 10.1089/ten.tea.2019.0009 Schmitt M. , Friedrich O. , Gilbert D. :Portoporator©: A portable low-cost electroporation device for gene transfer to cultured cells in biotechnology, biomedical research and education Biosensors and Bioelectronics 131 2019 ), S. 95-103 ISSN: 0956-5663 10.1016/j.bios.2019.02.024 Steinmann S. , Kunze P. , Hampel C. , Eckstein M. , Bertram Bramsen J. , Muenzner JK. , Carlé BE. , Ndreshkjana B. , Kemenes S. , Gasparini P. , Friedrich O. , Andersen C. , Geppert C. , Wang S. , Eyupoglu I. , Bäuerle T. , Hartmann A. , Schneider-Stock R. :DAPK1 loss triggers tumor invasion in colorectal tumor cells Cell Death & Disease 10 2019 ), Art.Nr.: 895 ISSN: 2041-4889 10.1038/s41419-019-2122-z Von Bomhard A. , Elsaesser A. , Riepl R. , Pippich K. , Faust J. , Schwarz S. , Körber L. , Breiter R. , Rotter N. :Cartilage regeneration using decellularized cartilage matrix: Long-term comparison of subcutaneous and intranasal placement in a rabbit model Journal of Cranio-Maxillofacial Surgery 47 2019 ), S. 682-694 ISSN: 1010-5182 10.1016/j.jcms.2019.01.010 Çapcı A. , Lorion MM. , Wang H. , Simon N. , Leidenberger M. , Borges Silva MC. , Moreira DR. , Zhu Y. , Meng Y. , Chen JY. , Lee YM. , Friedrich O. , Kappes B. , Wang J. , Ackermann L. , Tsogoeva S. :Artemisinin–(Iso)quinoline Hybrids by C−H Activation and Click Chemistry: Combating Multidrug-Resistant Malaria Angewandte Chemie International Edition 2019 )ISSN: 1433-7851 10.1002/anie.201907224
2018 2018
Capci Karagöz A. , Reiter C. , Seo EJ. , Gruber L. , Hahn F. , Leidenberger M. , Klein V. , Hampel F. , Friedrich O. , Marschall M. , Kappes B. , Efferth T. , Tsogoeva S. :Access to new highly potent antileukemia, antiviral and antimalarial agents via hybridization of natural products (homo)egonol, thymoquinone and artemisinin Bioorganic & Medicinal Chemistry 26 2018 ), S. 3610-3618 ISSN: 0968-0896 10.1016/j.bmc.2018.05.041 Friedrich O. , Diermeier S. , Larsson L. :Weak by the machines: muscle motor protein dysfunction - a side effect of intensive care unit treatment. Acta Physiologica 222 2018 ), Art.Nr.: e12885 ISSN: 1748-1708 10.1111/apha.12885 Fröhlich T. , Hahn F. , Belmudes L. , Leidenberger M. , Friedrich O. , Kappes B. , Coute Y. , Marschall M. , Tsogoeva S. :Synthesis of Artemisinin-Derived Dimers, Trimers and Dendrimers: Investigation of Their Antimalarial and Antiviral Activities Including Putative Mechanisms of Action Chemistry - A European Journal 24 2018 ), S. 8103-8113 ISSN: 0947-6539 10.1002/chem.201800729 Fröhlich T. , Kiss A. , Wolfling J. , Mernyak E. , Kulmany AE. , Minorics R. , Zupko I. , Leidenberger M. , Friedrich O. , Kappes B. , Hahn F. , Marschall M. , Schneider G. , Tsogoeva S. :Synthesis of Artemisinin-Estrogen Hybrids Highly Active against HCMV, P-falciparum, and Cervical and Breast Cancer ACS Medicinal Chemistry Letters 9 2018 ), S. 1128-1133 ISSN: 1948-5875 10.1021/acsmedchemlett.8b00381 Fröhlich T. , Reiter C. , Saeed MEM. , Hutterer C. , Hahn F. , Leidenberger M. , Friedrich O. , Kappes B. , Marschall M. , Efferth T. , Tsogoeva S. :Synthesis of Thymoquinone-Artemisinin Hybrids: New Potent Antileukemia, Antiviral, and Antimalarial Agents ACS Medicinal Chemistry Letters 9 2018 ), S. 534-539 ISSN: 1948-5875 10.1021/acsmedchemlett.7b00412 Haug M. , Reischl B. , Prölß G. , Pollmann C. , Buckert T. , Keidel C. , Schürmann S. , Hock M. , Rupitsch S. , Heckel M. , Pöschel T. , Scheibel T. , Haynl C. , Kiriaev L. , Head SI. , Friedrich O. :The MyoRobot: A novel automated biomechatronics system to assess voltage/Ca2+ biosensors and active/passive biomechanics in muscle and biomaterials Biosensors and Bioelectronics 102 2018 ), S. 589-599 ISSN: 0956-5663 10.1016/j.bios.2017.12.003 Knieling F. , Menezes JG. , Claussen J. , Schwarz M. , Neufert C. , Fahlbusch FB. , Rath T. , Thoma OM. , Kramer V. , Menchicchi B. , Kersten C. , Scheibe K. , Schürmann S. , Carlé BE. , Rascher W. , Neurath M. , Ntziachristos V. , Waldner M. :Raster-Scanning Optoacoustic Mesoscopy for Gastrointestinal Imaging at High Resolution Gastroenterology 154 2018 ), S. 807-809.e3 ISSN: 0016-5085 10.1053/j.gastro.2017.11.285 Li JJ. , Akey A. , Dunstan C. , Vielreicher M. , Friedrich O. , Bell DC. , Zreiqat H. :Effects of Material-Tissue Interactions on Bone Regeneration Outcomes Using Advanced Healthcare Materials 7 2018 ), Art.Nr.: e1800218 ISSN: 2192-2640 10.1002/adhm.201800218 Milanos S. , Künzel K. , Gilbert D. , Janzen D. , Sasi M. , Büttner A. , Frimurer TM. , Villmann C. :Structural changes at the myrtenol backbone reverse its positive allosteric potential into inhibitory GABAA receptor modulation. Biological Chemistry 2018 )ISSN: 1431-6730 10.1515/hsz-2017-0262 Reiling SJ. , Krohne G. , Friedrich O. , Geary TG. , Rohrbach P. :Chloroquine exposure triggers distinct cellular responses in sensitive versus resistant Plasmodium falciparum parasites Scientific Reports 8 2018 ), Art.Nr.: 11137 ISSN: 2045-2322 10.1038/s41598-018-29422-6 Reisbeck M. , Richter L. , Helou MJ. , Arlinghaus S. , Anton B. , van Dommelen I. , Nitzsche M. , Bassler M. , Kappes B. , Friedrich O. , Hayden O. :Hybrid integration of scalable mechanical and magnetophoretic focusing for magnetic flow cytometry Biosensors and Bioelectronics 109 2018 ), S. 98-108 ISSN: 0956-5663 10.1016/j.bios.2018.02.046 Scharin-Mehlmann M. , Häring A. , Rommel M. , Dirnecker T. , Friedrich O. , Frey L. , Gilbert D. :Nano- and micro-patterned S-, H-, and X-PDMS for cell-based applications: Comparison of wettability, roughness, and cell-derived parameters Frontiers in Bioengineering and Biotechnology 6 2018 ), Art.Nr.: 51 ISSN: 2296-4185 10.3389/fbioe.2018.00051 Schneidereit D. , Nübler S. , Prölß G. , Reischl B. , Schürmann S. , Müller OJ. , Friedrich O. :Optical prediction of single muscle fiber force production using a combined biomechatronics and second harmonic generation imaging approach Light: Science & Applications 7 2018 ), Art.Nr.: 79 ISSN: 2047-7538 10.1038/s41377-018-0080-3 Schneidereit D. , Schürmann S. , Friedrich O. :PiezoGRIN: A High-Pressure Chamber Incorporating GRIN Lenses for High-Resolution 3D-Microscopy of living Cells and Tissues Advanced Science 2018 ), Art.Nr.: 1801453 ISSN: 2198-3844 10.1002/advs.201801453 Schneidereit D. , Tschernich J. , Friedrich O. , Scharin-Mehlmann M. , Gilbert D. :3D-Printed Reusable Cell Culture Chamber with Integrated Electrodes for Electrical Stimulation and Parallel Microscopic Evaluation 3D Printing and Additive Manufacturing 5 2018 ), S. 115-125 ISSN: 2329-7662 10.1089/3dp.2017.0103 Simon N. , Friedrich O. , Kappes B. :Quantification of human complement factor H binding to asexual malaria blood stages by an enzyme-linked immunosorbent assay Vaccine 36 2018 ), S. 1545-1547 ISSN: 0264-410X 10.1016/j.vaccine.2018.01.080 Ugele M. , Weniger M. , Leidenberger M. , Huang Y. , Bassler M. , Friedrich O. , Kappes B. , Hayden O. , Richter L. :Label-free, high-throughput detection of P-falciparum infection in sphered erythrocytes with digital holographic microscopy Lab on A Chip 18 2018 ), S. 1704-1712 ISSN: 1473-0197 10.1039/c8lc00350e Ugele M. , Weniger M. , Stanzel M. , Bassler M. , Krause S. , Friedrich O. , Hayden O. , Richter L. :Label-Free High-Throughput Leukemia Detection by Holographic Microscopy Advanced Science 5 2018 )ISSN: 2198-3844 10.1002/advs.201800761 Vielreicher M. , Kralisch D. , Sternal F. , Arkudas A. , Friedrich O. , Völkl S. :Bacterial nanocellulose stimulates mesenchymal stem cell expansion and formation of stable collagen-I networks as a novel biomaterial in tissue engineering Scientific Reports 8 2018 )ISSN: 2045-2322 10.1038/s41598-018-27760-z Walzik MP. , Vollmar V. , Lachnit T. , Dietz H. , Haug S. , Bachmann H. , Fath M. , Aschenbrenner D. , Mofrad SA. , Friedrich O. , Gilbert D. :Corrigendum to "A portable low-cost long-term live-cell imaging platform for biomedical research and education" [Biosens. Bioelectron. 64 (2015) 639-649]. Biosensors and Bioelectronics 99 2018 ), S. 683 ISSN: 0956-5663 10.1016/j.bios.2017.08.021
2017 2017
Bock C. , Gangajji P. , Bönisch S. , Bauer W. , Hutterer C. , Leidenberger M. , Friedrich O. , Marschall M. , Kappes B. , Görling A. , Tsogoeva S. :Deeper Insight into the Six-Step Domino Reaction of Aldehydes with Malononitrile and Evaluation of Antiviral and Antimalarial Activities of the Obtained Bicyclic Products. ChemistryOpen 6 2017 ), S. 364-374 ISSN: 2191-1363 10.1002/open.201700005 Diermeier S. , Buttgereit A. , Schürmann S. , Winter L. , Xu H. , Murphy RM. , Clemen CS. , Schröder R. , Friedrich O. :Preaged remodeling of myofibrillar cytoarchitecture in skeletal muscle expressing R349P mutant desmin Neurobiology of Aging 58 2017 ), S. 77-87 ISSN: 0197-4580 10.1016/j.neurobiolaging.2017.06.001 Diermeier S. , Iberl J. , Vetter K. , Haug M. , Pollmann C. , Reischl B. , Buttgereit A. , Schürmann S. , Spörrer M. , Goldmann W. , Fabry B. , Elhamine F. , Stehle R. , Pfitzer G. , Winter L. , Clemen CS. , Herrmann H. , Schröder R. , Friedrich O. :Early signs of architectural and biomechanical failure in isolated myofibers and immortalized myoblasts from desmin-mutant knock-in mice Scientific Reports 7 2017 ), S. 1391 ISSN: 2045-2322 10.1038/s41598-017-01485-x Friedrich O. , Head S. :Quantitative Ratiometric Ca(2+) Imaging to Assess Cell Viability. Methods in Molecular Biology 1601 2017 ), S. 171-193 ISSN: 1064-3745 10.1007/978-1-4939-6960-9_14 Friedrich O. , Schneidereit D. , Nikolaev YA. , Nikolova-Krstevski V. , Schürmann S. , Wirth-Hücking A. , Merten AL. , Fatkin D. , Martinac B. :Adding dimension to cellular mechanotransduction: Advances in biomedical engineering of multiaxial cell-stretch systems and their application to cardiovascular biomechanics and mechano-signaling. Progress in biophysics and molecular biology 2017 )ISSN: 1873-1732 10.1016/j.pbiomolbio.2017.06.011 Fröhlich T. , Reiter C. , Ibrahim MM. , Beutel J. , Hutterer C. , Zeitträger I. , Bahsi H. , Leidenberger M. , Friedrich O. , Kappes B. , Efferth T. , Marschall M. , Tsogoeva S. :Synthesis of Novel Hybrids of Quinazoline and Artemisinin with High Activities against Plasmodium falciparum, Human Cytomegalovirus, and Leukemia Cells ACS Omega 2 2017 ), S. 2422-2431 ISSN: 2470-1343 10.1021/acsomega.7b00310 Gilbert D. :Maßgeschneiderte Methoden und Technologien für high content imaging BioSpektrum 23. Jahrgang 2017 ), S. 286-288 ISSN: 0947-0867 10.1007/s12268-017-0798-0 Gilbert D. , Friedrich O. , Schneidereit D. , Meier JC. , Kraus L. :Step-by-step guide to building an inexpensive 3D printed motorized positioning stage for automated high-content screening microscopy. Biosensors and Bioelectronics 92 2017 ), S. 472-481 ISSN: 0956-5663 10.1016/j.bios.2016.10.078 Kravic B. , Harbauer AB. , Romanello V. , Simeone L. , Vögtle FN. , Kaiser T. , Straubinger M. , Huraskin D. , Böttcher M. , Cerqua C. , Martin ED. , Poveda-Huertes D. , Buttgereit A. , Rabalski AJ. , Heuss D. , Rudolf R. , Friedrich O. , Litchfield D. , Marber M. , Salviati L. , Mougiakakos D. , Neuhuber W. , Sandri M. , Meisinger C. , Hashemolhosseini S. :In mammalian skeletal muscle, phosphorylation of TOMM22 by protein kinase CSNK2/CK2 controls mitophagy Autophagy 2017 ), S. 1-65 ISSN: 1554-8627 10.1080/15548627.2017.1403716 Leidenberger M. , Voigtländer C. , Simon N. , Kappes B. :Green I-Based Fluorescence Assay to Assess Cell Viability of Malaria Parasites for Routine Use in Compound Screening. Methods in Molecular Biology 1601 2017 ), S. 97-110 ISSN: 1064-3745 10.1007/978-1-4939-6960-9_9 Menzner AK. , Abolpour Mofrad S. , Friedrich O. , Gilbert D. :Corrigendum to "Towards in vitro DT/DNT testing: Assaying chemical susceptibility in early differentiating NT2 cells" [Toxicology 338 (2015) 69-76]. Toxicology 389 2017 ), S. 108 ISSN: 1879-3185 10.1016/j.tox.2017.08.001 Resheq YJ. , Menzner AK. , Bosch J. , Tickle J. , Li KK. , Wilhelm A. , Hepburn E. , Murihead G. , Ward ST. , Curbishley SM. , Zimmermann HW. , Bruns T. , Gilbert D. , Tripal P. , Mackensen A. , Adams DH. , Weston CJ. :Impaired Transmigration of Myeloid-Derived Suppressor Cells across Human Sinusoidal Endothelium Is Associated with Decreased Expression of CD13 Journal of Immunology 2017 )ISSN: 0022-1767 10.4049/jimmunol.1600466 Taeger CD. , Friedrich O. , Horch RE. , Drechsler C. , Weigand A. , Hopf F. , Geppert C. , Münch F. , Birkholz T. , Wenzel C. , Geis S. , Prantl L. , Buchholz R. , Präbst K. :Extracorporeal perfusion - reduced to a one-way infusion. Clinical hemorheology and microcirculation 2017 )ISSN: 1875-8622 10.3233/CH-170298 Vielreicher M. , Friedrich O. :Assessment of Population and ECM Production Using Multiphoton Microscopy as an Indicator of Cell Viability. Methods in Molecular Biology 1601 2017 ), S. 243-255 ISSN: 1064-3745 10.1007/978-1-4939-6960-9_19 Waldner M. , Rath T. , Schürmann S. , Bojarski C. , Atreya R. :Imaging of Mucosal Inflammation: Current Technological Developments, Clinical Implications, and Future Perspectives Frontiers in Immunology 8 2017 )ISSN: 1664-3224 10.3389/fimmu.2017.01256 Wrosch JK. , Volbers B. , Gölitz P. , Gilbert D. , Schwab S. , Dörfler A. , Kornhuber J. , Groemer TW. :Corrigendum: Feasibility and Diagnostic Accuracy of Ischemic Stroke Territory Recognition Based on Two-dimensional Projections of Three-dimensional Diffusion MRI Data Frontiers in Neurology 8 2017 ), S. 56 ISSN: 1664-2295 10.3389/fneur.2017.00056
2016 2016
Abolpour Mofrad S. , Künzel K. , Friedrich O. , Gilbert D. :Optimizing neuronal differentiation of human pluripotent NT2 stem cells in monolayer cultures. Development, growth & differentiation 58 2016 ), S. 664-676 ISSN: 1440-169X 10.1111/dgd.12323 Chernavskaia O. , Heuke S. , Friedrich O. , Schürmann S. , Atreya R. , Stallmach A. , Neurath M. , Waldner M. , Petersen I. , Schmitt M. , Bocklitz T. , Popp J. , Vieth M. :Beyond endoscopic assessment in inflammatory bowel disease: real-time histology of disease activity by non-linear multimodal imaging. Scientific Reports 6 2016 ), S. 29239 ISSN: 2045-2322 10.1038/srep29239 Dakhil H. , Gilbert D. , Malhotra D. , Limmer A. , Engelhardt H. , Amtmann A. , Hansmann J. , Hübner H. , Buchholz R. , Friedrich O. , Wierschem A. :Measuring average rheological quantities of cell monolayers in the linear viscoelastic regime Rheologica Acta 55 2016 ), S. 527-536 ISSN: 0035-4511 10.1007/s00397-016-0936-5 Diermeier S. , Buttgereit A. , Clemen C. , Schröder R. , Friedrich O. :Aging-related progressive skeletal muscle weakness in mutant DesR349P muscles: a matter of compromised cytoarchitecture Acta Physiologica 216 2016 )ISSN: 1748-1708 Gilbert D. , Stebbing MJ. , Künzel K. , Murphy RM. , Zacharewicz E. , Buttgereit A. , Stokes L. , Adams DJ. , Friedrich O. :Store-Operated Ca(2+) Entry (SOCE) and Purinergic Receptor-Mediated Ca(2+) Homeostasis in Murine bv2 Microglia Cells: Early Cellular Responses to ATP-Mediated Microglia Activation. Frontiers in Molecular Neuroscience 9 2016 ), S. 111 ISSN: 1662-5099 10.3389/fnmol.2016.00111 Künzel K. , Friedrich O. , Gilbert D. :A Recombinant Human Pluripotent Stem Cell Line Stably Expressing Halide-Sensitive YFP-I152L for GABAAR and GlyR-Targeted High-Throughput Drug Screening and Toxicity Testing. Frontiers in Molecular Neuroscience 9 2016 ), Art.Nr.: 51 ISSN: 1662-5099 10.3389/fnmol.2016.00051 Larsson L. , Friedrich O. :Critical Illness Myopathy (CIM) and Ventilator-Induced Diaphragm Muscle Dysfunction (VIDD): Acquired Myopathies Affecting Contractile Proteins. Comprehensive Physiology 7 2016 ), S. 105-112 ISSN: 2040-4603 10.1002/cphy.c150054 Olah T. , Bodnar D. , Toth A. , Vincze J. , Fodor J. , Reischl B. , Kovacs A. , Ruzsnavszky O. , Dienes B. , Szentesi P. , Friedrich O. , Csernoch L. :Cannabinoid signalling inhibits sarcoplasmic Ca(2+) release and regulates excitation-contraction coupling in mammalian skeletal muscle. The Journal of Physiology 594 2016 ), S. 7381-7398 ISSN: 0022-3751 10.1113/JP272449 Reisbeck M. , Helou MJ. , Richter L. , Kappes B. , Friedrich O. , Hayden O. :Magnetic fingerprints of rolling cells for quantitative flow cytometry in whole blood. Scientific Reports 6 2016 ), S. 32838 ISSN: 2045-2322 10.1038/srep32838 Schneidereit D. , Vass H. , Reischl B. , Allen RJ. , Friedrich O. :Calcium Sensitive Fluorescent Dyes Fluo-4 and Fura Red under Pressure: Behaviour of Fluorescence and Buffer Properties under Hydrostatic Pressures up to 200 MPa. PLoS ONE 11 2016 ), S. e0164509 ISSN: 1932-6203 10.1371/journal.pone.0164509 Schürmann S. , Wagner S. , Herlitze S. , Fischer C. , Gumbrecht S. , Wirth-Hücking A. , Prölß G. , Lautscham L. , Fabry B. , Goldmann W. , Nikolova-Krstevski V. , Martinac B. , Friedrich O. :The IsoStretcher: An isotropic cell stretch device to study mechanical biosensor pathways in living cells. Biosensors and Bioelectronics 81 2016 ), S. 363-72 ISSN: 0956-5663 10.1016/j.bios.2016.03.015 Spitzer P. , Condic M. , Herrmann M. , Oberstein T. , Scharin-Mehlmann M. , Gilbert D. , Friedrich O. , Groemer T. , Kornhuber J. , Lang R. , Maler JM. :Amyloidogenic amyloid-?-peptide variants induce microbial agglutination and exert antimicrobial activity Scientific Reports 6 2016 ), S. 32228 ISSN: 2045-2322 10.1038/srep32228 Taeger C. , Friedrich O. , Drechsler C. , Weigand A. , Hobe F. , Geppert C. , Münch F. , Birkholz T. , Buchholz R. , Horch RE. , Präbst K. , Buchholz R. :Hydroxyethyl starch solution for extracorporeal tissue perfusion Clinical hemorheology and microcirculation 2016 )ISSN: 1875-8622 10.3233/CH-162049 Vielreicher M. , Friedrich O. :Nichtinvasive Hochleistungstechnik zur Gewebeuntersuchung. Multiphotonen-Mikroskopie stellt Kollagen-I-Netzwerk in Knochen dar Orthopädie & Rheuma 16 2016 ), S. 38-43 ISSN: 1435-0017 10.1007/s15002-016-0984-3 https://www.springermedizin.de/multiphotonen-mikroskopie-stellt-kollagen-i-netzwerke-in-knochen/10854042
2015 2015
Auernheimer V. , Lautscham L. , Leidenberger M. , Friedrich O. , Kappes B. , Fabry B. , Goldmann W. :Vinculin phosphorylation at residues Y100 and Y1065 is required for cellular force transmission. Journal of cell science 2015 )ISSN: 1477-9137 10.1242/jcs.172031 http://jcs.biologists.org/content/early/2015/07/31/jcs.172031 Clemen C. , Stöckigt F. , Strucksberg KH. , Chevessier F. , Winter L. , Schütz J. , Bauer R. , Thorweihe JM. , Wenzel D. , Schlötzer-Schrehardt U. , Rasche V. , Krsmanovic P. , Katus H. , Rottbauer W. , Just S. , Müller OJ. , Friedrich O. , Meyer R. , Herrmann H. , Schrickel JW. , Schröder R. :The toxic effect of R350P mutant desmin in striated muscle of man and mouse. Acta Neuropathologica 129 2015 ), S. 297-315 ISSN: 0001-6322 10.1007/s00401-014-1363-2 http://link.springer.com/article/10.1007%2Fs00401-014-1363-2 Dakhil H. , Wierschem A. , Gilbert D. , Amtmann A. , Hübner H. , Buchholz R. , Friedrich O. :Viscoelastic Measurements of Cells in a Rotational Rheometer Chemie Ingenieur Technik 87 2015 ), S. 1106 ISSN: 0009-286X Friedrich O. , Reid M. , van den Berghe G. , Vanhorebeek I. , Hermans G. , Rich MM. , Larsson L. :The sick and the weak: Neuropathies/ myopathies in the critically ill Physiological Reviews 95 2015 ), S. 1025-1109 ISSN: 1522-1210 10.1152/physrev.00028.2014 Head SI. , Chan S. , Houweling PJ. , Quinlan KGR. , Murphy R. , Wagner S. , Friedrich O. , North KN. :Altered Ca2+ Kinetics Associated with alpha-Actinin-3 Deficiency May Explain Positive Selection for ACTN3 Null Allele in Human Evolution PLoS Genetics 11 2015 ), Art.Nr.: e1004862 ISSN: 1553-7390 10.1371/journal.pgen.1004862 Künzel K. , Abolpour Mofrad S. , Friedrich O. , Gilbert D. :Establishment and validation of recombinant cell lines for high-throughput DNT testing Acta Physiologica 213 2015 ), S. 78-79 ISSN: 1748-1708 Menzner AK. , Abolpour Mofrad S. , Friedrich O. , Gilbert D. :Towards in vitro DT/DNT testing: Assaying chemical susceptibility in early differentiating NT2 cells. Toxicology 338 2015 ), S. 69-76 ISSN: 0300-483X 10.1016/j.tox.2015.10.007 Reiter C. , Fröhlich T. , Gruber L. , Hutterer C. , Marschall M. , Voigtländer C. , Friedrich O. , Kappes B. , Efferth T. , Tsogoeva S. :Highly potent artemisinin-derived dimers and trimers: Synthesis and evaluation of their antimalarial, antileukemia and antiviral activities. Bioorganic & medicinal chemistry 2015 )ISSN: 1464-3391 10.1016/j.bmc.2015.07.048 http://www.sciencedirect.com/science/article/pii/S096808961500632X Reiter C. , Fröhlich T. , Zeino M. , Marschall M. , Bahsi H. , Leidenberger M. , Friedrich O. , Kappes B. , Hampel F. , Efferth T. , Tsogoeva S. :New efficient artemisinin derived agents against human leukemia cells, human cytomegalovirus and Plasmodium falciparum: 2nd generation 1,2,4-trioxane-ferrocene hybrids. European journal of medicinal chemistry 97 2015 ), S. 164-72 ISSN: 1768-3254 10.1016/j.ejmech.2015.04.053 http://www.sciencedirect.com/science/article/pii/S0223523415300179 Ritterhoff J. , Völkers M. , Seitz A. , Spaich K. , Gao E. , Peppel K. , Pleger S. , Zimmermann W. , Friedrich O. , Fink R. , Koch W. , Katus H. , Most P. :S100A1 DNA-based Inotropic Therapy Protects Against Proarrhythmogenic Ryanodine Receptor 2 Dysfunction. Molecular Therapy 23 2015 ), S. 1320-30 ISSN: 1525-0016 10.1038/mt.2015.93 http://www.nature.com/mt/journal/v23/n8/full/mt201593a.html Sinner B. , Friedrich O. , Lindner R. , Bundscherer A. , Graf B. :Long-term NMDA receptor inhibition affects NMDA receptor expression and alters glutamatergic activity in developing rat hippocampal neurons. Toxicology 333 2015 ), S. 147-55 ISSN: 1879-3185 10.1016/j.tox.2015.04.017 http://www.sciencedirect.com/science/article/pii/S0300483X15000888 Taeger C. , Friedrich O. , Dragu A. , Weigand A. , Hobe F. , Drechsler C. , Geppert C. , Arkudas A. , Münch F. , Buchholz R. , Pollmann C. , Schramm A. , Birkholz T. , Horch RE. , Präbst K. , Buchholz R. :Assessing viability of extracorporeal preserved muscle transplants using external field stimulation: a novel tool to improve methods prolonging bridge-to-transplantation time. Scientific Reports 5 2015 ), S. 11956 ISSN: 2045-2322 10.1038/srep11956 Vielreicher M. , Gellner M. , Rottensteiner U. , Horch RE. , Arkudas A. , Friedrich O. :Multiphoton microscopy analysis of extracellular collagen I network formation by mesenchymal stem cells. Journal of Tissue Engineering and Regenerative Medicine 11 2015 ), S. 2104-2115 ISSN: 1932-7005 10.1002/term.2107 Wagner S. , Schürmann S. , Schüttler J. , Hein S. , Friedrich O. :Septic cardiomyopathy in rat LPS-induced endotoxemia: relative contribution of cellular diastolic Ca2+ removal pathways, myofibrillar biomechanics properties and action of the cardiotonic drug levosimendan Basic research in cardiology 110 2015 ), S. 507 ISSN: 1435-1803 10.1007/s00395-015-0507-4 http://link.springer.com/article/10.1007/s00395-015-0507-4 Walzik MP. , Vollmar V. , Lachnit T. , Dietz H. , Haug S. , Bachmann H. , Fath M. , Aschenbrenner D. , Abolpour Mofrad S. , Friedrich O. , Gilbert D. :A portable low-cost long-term live-cell imaging platform for biomedical research and education. Biosensors and Bioelectronics 64 2015 ), S. 639-49 ISSN: 0956-5663 10.1016/j.bios.2014.09.061 http://www.sciencedirect.com/science/article/pii/S0956566314007489 Wrosch JK. , Volbers B. , Gölitz P. , Gilbert D. , Schwab S. , Dörfler A. , Kornhuber J. , Groemer TW. :Feasibility and Diagnostic Accuracy of Ischemic Stroke Territory Recognition Based on Two-Dimensional Projections of Three-Dimensional Diffusion MRI Data. Frontiers in Neurology 2015 )ISSN: 1664-2295 10.3389/fneur.2015.00239
2014 2014
Buttgereit A. , Weber C. , Friedrich O. :A novel quantitative morphometry approach to assess regeneration in dystrophic skeletal muscle. Neuromuscular Disorders 24 2014 ), S. 596-603 ISSN: 0960-8966 10.1016/j.nmd.2014.04.011 http://www.nmd-journal.com/article/S0960-8966%2814%2900113-8/abstract Edwards JN. , Weber C. , Liu I. , Reischl B. , Most P. , Wirth-Hücking A. , Yi B. , Friedrich O. , Voelkers M. , Buttgereit A. , Lang R. , Lee A. , Polyak F. , Von Wegner F. , Cully TR. :IL-1α reversibly inhibits skeletal muscle ryanodine receptor a novel mechanism for critical illness myopathy? American journal of respiratory cell and molecular biology 50 2014 ), S. 1096-1106 ISSN: 1535-4989 10.1165/rcmb.2013-0059OC Friedrich O. :'Set the controls...' - phenotype matching beyond genetics in muscular dystrophy Experimental physiology 99 2014 ), S. 638-639 ISSN: 1469-445X 10.1113/expphysiol.2014.077933 http://onlinelibrary.wiley.com/doi/10.1113/expphysiol.2014.077933/full Friedrich O. , Reiling S. , Wunderlich J. , Rohrbach P. :Assessment of Plasmodium falciparum PfMDR1 transport rates using Fluo-4. Journal of cellular and molecular medicine 18 2014 ), S. 1851-62 ISSN: 1582-4934 10.1111/jcmm.12313 http://onlinelibrary.wiley.com/doi/10.1111/jcmm.12313/abstract Kolb T. , Albert S. , Haug M. , Whyte G. :Optofluidic rotation of living cells for single-cell tomography Journal of Biophotonics 8 2014 ), S. 239-246 ISSN: 1864-063X 10.1002/jbio.201300196 Taskin S. , Stumpf VI. , Bachmann J. , Weber C. , Martignoni ME. , Friedrich O. :Motor protein function in skeletal abdominal muscle of cachectic cancer patients. Journal of cellular and molecular medicine 18 2014 ), S. 69-79 ISSN: 1582-4934 10.1111/jcmm.12165 http://onlinelibrary.wiley.com/doi/10.1111/jcmm.12165/abstract;jsessionid=E5BDFC4245413F048ECA099352DF0B8B.f02t04
2013 2013
Balansa W. , Islam R. , Fontaine F. , Piggott A. , Zhang H. , Xiao X. , Webb T. , Gilbert D. , Lynch J. , Capon R. :Sesterterpene glycinyl-lactams: a new class of glycine receptor modulator from Australian marine sponges of the genus Psammocinia. Organic & biomolecular chemistry 11 2013 ), S. 4695-701 ISSN: 1477-0539 10.1039/c3ob40861b Balansa W. , Islam R. , Gilbert D. , Fontaine F. , Xiao X. , Zhang H. , Piggott A. , Lynch J. , Capon R. :Australian marine sponge alkaloids as a new class of glycine-gated chloride channel receptor modulator. Bioorganic & medicinal chemistry 21 2013 ), S. 4420-5 ISSN: 1464-3391 10.1016/j.bmc.2013.04.061 Buttgereit A. , Weber C. , Garbe CS. , Friedrich O. :From chaos to split-ups - SHG microscopy reveals a specific remodelling mechanism in ageing dystrophic muscle Journal of Pathology 229 2013 ), S. 477-85 ISSN: 0022-3417 10.1002/path.4136 Börner K. , Niopek D. , Cotugno G. , Kaldenbach M. , Pankert T. , Willemsen J. , Zhang X. , Schürmann N. , Mockenhaupt S. , Serva A. , Hiet M. , Wiedtke E. , Castoldi M. , Starkuviene V. , Erfle H. , Gilbert D. , Bartenschlager R. , Boutros M. , Binder M. , Streetz K. , Kräusslich H. , Grimm D. :Robust RNAi enhancement via human Argonaute-2 overexpression from plasmids, viral vectors and cell lines. Nucleic Acids Research 41 2013 ), S. e199 ISSN: 0305-1048 10.1093/nar/gkt836 Jung J. , Weisenburger S. , Albert S. , Gilbert D. , Friedrich O. , Eulenburg V. , Kornhuber J. , Groemer TW. :Performance of scientific cameras with different sensor types in measuring dynamic processes in fluorescence microscopy. Microscopy research and technique 76 2013 ), S. 835-43 ISSN: 1097-0029 10.1002/jemt.22236 Kuhns S. , Schmidt K. , Reymann J. , Gilbert D. , Neuner A. , Hub B. , Carvalho R. , Wiedemann P. , Zentgraf H. , Erfle H. , Klingmüller U. , Boutros M. , Pereira G. :The microtubule affinity regulating kinase MARK4 promotes axoneme extension during early ciliogenesis. The Journal of Cell Biology 200 2013 ), S. 505-22 ISSN: 0021-9525 10.1083/jcb.201206013 Lang N. , Münster S. , Metzner C. , Krauß P. , Schürmann S. , Lange J. , Aifantis KE. , Friedrich O. , Fabry B. :Estimating the 3D pore size distribution of biopolymer networks from directionally biased data. Biophysical Journal 105 2013 ), S. 1967-75 ISSN: 0006-3495 10.1016/j.bpj.2013.09.038 http://www.sciencedirect.com/science/article/pii/S0006349513010862 Schürmann S. , Försch S. , Atreya R. , Neumann H. , Friedrich O. , Neurath M. , Waldner M. :Label-free imaging of inflammatory bowel disease using multiphoton microscopy. Gastroenterology 145 2013 ), S. 514-6 ISSN: 0016-5085 10.1053/j.gastro.2013.06.054 http://www.gastrojournal.org/article/S0016-5085%2813%2900998-0/fulltext Talwar S. , Lynch J. , Gilbert D. :Fluorescence-based high-throughput functional profiling of ligand-gated ion channels at the level of single cells. PLoS ONE 8 2013 ), S. e58479 ISSN: 1932-6203 10.1371/journal.pone.0058479 Vielreicher M. , Schürmann S. , Detsch R. , Schmidt M. , Buttgereit A. , Boccaccini AR. , Friedrich O. :Taking a deep look: modern microscopy technologies to optimize the design and functionality of biocompatible scaffolds for tissue engineering in regenerative medicine Journal of the Royal Society Interface 10 2013 ), S. 20130263 ISSN: 1742-5689 10.1098/rsif.2013.0263 http://rsif.royalsocietypublishing.org/content/10/86/20130263
2012 2012
Cully TR. , Edwards JN. , Friedrich O. , Stephenson DG. , Murphy RM. , Launikonis BS. :Changes in plasma membrane Ca-ATPase and stromal interacting molecule 1 expression levels for Ca(2+) signaling in dystrophic mdx mouse muscle. American journal of physiology. Cell physiology 303 2012 ), S. C567-76 ISSN: 1522-1563 10.1152/ajpcell.00144.2012 http://ajpcell.physiology.org/content/303/5/C567 Friedrich O. , Wagner S. , Battle A. , Schürmann S. , Martinac B. :Mechano-regulation of the beating heart at the cellular level - Mechanosensitive channels in normal and diseased heart Progress in Biophysics & Molecular Biology 110 2012 ), S. 226-238 ISSN: 0079-6107 10.1016/j.pbiomolbio.2012.08.009 Garbe CS. , Buttgereit A. , Schürmann S. , Friedrich O. :Automated multiscale morphometry of muscle disease from second harmonic generation microscopy using tensor-based image processing. IEEE transactions on bio-medical engineering 59 2012 ), S. 39-44 ISSN: 1558-2531 10.1109/TBME.2011.2167325 http://ieeexplore.ieee.org/xpl/articleDetails.jsp?arnumber=6015536 Wagner S. , Knipp S. , Weber C. , Hein S. , Schinkel S. , Walther A. , Bekeredjian R. , Müller OJ. , Friedrich O. :The heart in Duchenne muscular dystrophy: early detection of contractile performance alteration. Journal of cellular and molecular medicine 16 2012 ), S. 3028-36 ISSN: 1582-4934 10.1111/j.1582-4934.2012.01630.x http://onlinelibrary.wiley.com/doi/10.1111/j.1582-4934.2012.01630.x/abstract
2011 2011
Edwards JN. , Blackmore D. , Gilbert D. , Murphy R. , Launikonis BS. :Store-operated calcium entry remains fully functional in aged mouse skeletal muscle despite a decline in STIM1 protein expression. Aging Cell 10 2011 ), S. 675-85 ISSN: 1474-9718 10.1111/j.1474-9726.2011.00706.x Gilbert D. , Erdmann G. , Zhang X. , Fritzsche A. , Demir K. , Jaedicke A. , Muehlenberg K. , Wanker E. , Boutros M. :A novel multiplex cell viability assay for high-throughput RNAi screening. PLoS ONE 6 2011 ), S. e28338 ISSN: 1932-6203 10.1371/journal.pone.0028338 Mohl MC. , Iismaa SE. , Xiao XH. , Friedrich O. , Wagner S. , Nikolova-Krstevski V. , Wu J. , Yu ZY. , Feneley M. , Fatkin D. , Allen DG. , Graham RM. :Regulation of murine cardiac contractility by activation of α(1A)-adrenergic receptor-operated Ca(2+) entry. Cardiovascular Research 91 2011 ), S. 310-9 ISSN: 0008-6363 10.1093/cvr/cvr081 http://cardiovascres.oxfordjournals.org/content/cardiovascres/91/2/310.full.pdf Sinner B. , Friedrich O. , Zausig Y. , Bein T. , Graf B. :Toxic effects of midazolam on differentiating neurons in vitro as a consequence of suppressed neuronal Ca 2+-oscillations Toxicology 290 2011 ), S. 96-101 ISSN: 0300-483X 10.1016/j.tox.2011.08.022 http://www.sciencedirect.com/science/article/pii/S0300483X1100326X Sinner B. , Friedrich O. , Zink W. , Zausig Y. , Graf B. :The toxic effects of s(+)-ketamine on differentiating neurons in vitro as a consequence of suppressed neuronal Ca2+ oscillations. Anesthesia and analgesia 113 2011 ), S. 1161-9 ISSN: 1526-7598 10.1213/ANE.0b013e31822747df http://journals.lww.com/anesthesia-analgesia/pages/articleviewer.aspx?year=2011&issue=11000&article=00033&type=abstract Völkers M. , Weidenhammer C. , Herzog N. , Qiu G. , Spaich K. , von Wegner F. , Peppel K. , Müller OJ. , Schinkel S. , Rabinowitz JE. , Hippe HJ. , Brinks H. , Katus H. , Koch WJ. , Eckhart AD. , Friedrich O. , Most P. :The inotropic peptide βARKct improves βAR responsiveness in normal and failing cardiomyocytes through G(βγ)-mediated L-type calcium current disinhibition. Circulation Research 108 2011 ), S. 27-39 ISSN: 1524-4571 10.1161/CIRCRESAHA.110.225201 http://circres.ahajournals.org/content/108/1/27
2010 2010
Balansa W. , Islam R. , Fontaine F. , Piggott A. , Zhang H. , Webb T. , Gilbert D. , Lynch J. , Capon R. :Ircinialactams: subunit-selective glycine receptor modulators from Australian sponges of the family Irciniidae. Bioorganic & medicinal chemistry 18 2010 ), S. 2912-9 ISSN: 1464-3391 10.1016/j.bmc.2010.03.002 Chung S. , Vanbellinghen J. , Mullins J. , Robinson A. , Hantke J. , Hammond C. , Gilbert D. , Freilinger M. , Ryan M. , Kruer M. , Masri A. , Gurses C. , Ferrie C. , Harvey K. , Shiang R. , Christodoulou J. , Andermann F. , Andermann E. , Thomas R. , Harvey R. , Lynch J. , Rees M. :Pathophysiological mechanisms of dominant and recessive GLRA1 mutations in hyperekplexia. The Journal of Neuroscience 30 2010 ), S. 9612-20 ISSN: 1529-2401 10.1523/JNEUROSCI.1763-10.2010 Edwards JN. , Friedrich O. , Cully TR. , von Wegner F. , Murphy RM. , Launikonis BS. :Upregulation of store-operated Ca2+ entry in dystrophic mdx mouse muscle. American journal of physiology. Cell physiology 299 2010 ), S. C42-50 ISSN: 1522-1563 10.1152/ajpcell.00524.2009 http://ajpcell.physiology.org/content/299/1/C42 Edwards JN. , Murphy RM. , Cully TR. , von Wegner F. , Friedrich O. , Launikonis BS. :Ultra-rapid activation and deactivation of store-operated Ca(2+) entry in skeletal muscle. Cell calcium 47 2010 ), S. 458-67 ISSN: 1532-1991 10.1016/j.ceca.2010.04.001 http://www.sciencedirect.com/science/article/pii/S0143416010000643 Friedrich O. :One arm is enough, two might actually be worse--when dystrophic muscle cells grow old. Experimental physiology 95 2010 ), S. 607-8 ISSN: 1469-445X 10.1113/expphysiol.2010.052621 http://onlinelibrary.wiley.com/doi/10.1113/expphysiol.2010.052621/abstract;jsessionid=F29D8110155C6F20FBEAE1A259AC4245.f01t03 Friedrich O. :Pressure, the nervous system and ion channels: Are humans too complicated? Undersea & Hyperbaric Medicine 37 2010 ), S. 241-243 ISSN: 1066-2936 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=78149275225∨igin=inward Friedrich O. , Both M. , Weber C. , Schürmann S. , Teichmann MDH. , von Wegner F. , Fink R. , Vogel M. , Chamberlain JS. , Garbe CS. :Microarchitecture is severely compromised but motor protein function is preserved in dystrophic mdx skeletal muscle. Biophysical Journal 98 2010 ), S. 606-16 ISSN: 0006-3495 10.1016/j.bpj.2009.11.005 http://www.cell.com/biophysj/abstract/S0006-3495%2809%2901728-7 Friedrich O. , Fink R. , von Wegner F. :New factors contributing to dynamic calcium regulation in the skeletal muscle triad-a crowded place Biophysical Reviews 2 2010 ), S. 29-38 ISSN: 1867-2450 10.1007/s12551-009-0027-2 Friedrich O. , Hund E. , von Wegner F. :Enhanced muscle shortening and impaired Ca2+ channel function in an acute septic myopathy model. Journal of Neurology 257 2010 ), S. 546-55 ISSN: 0340-5354 10.1007/s00415-009-5362-5 http://link.springer.com/article/10.1007%2Fs00415-009-5362-5 Gebhardt F. , Mitrovic A. , Gilbert D. , Vandenberg R. , Lynch J. , Dodd P. :Exon-skipping splice variants of excitatory amino acid transporter-2 (EAAT2) form heteromeric complexes with full-length EAAT2. Journal of Biological Chemistry 285 2010 ), S. 31313-24 ISSN: 0021-9258 10.1074/jbc.M110.153494 Schürmann S. , von Wegner F. , Fink R. , Friedrich O. , Vogel M. :Second harmonic generation microscopy probes different states of motor protein interaction in myofibrils Biophysical Journal 99 2010 ), S. 1842-1851 ISSN: 0006-3495 10.1016/j.bpj.2010.07.005 Völkers M. , Salz M. , Herzog N. , Frank D. , Dolatabadi N. , Frey N. , Gude N. , Friedrich O. , Koch WJ. , Katus H. , Sussmann MA. , Most P. :Orai1 and Stim1 regulate normal and hypertrophic growth in cardiomyocytes. Journal of molecular and cellular cardiology 48 2010 ), S. 1329-34 ISSN: 1095-8584 10.1016/j.yjmcc.2010.01.020 http://www.jmmc-online.com/article/S0022-2828%2810%2900033-7/abstract
2009 2009
Bartz F. , Kern L. , Erz D. , Zhu M. , Gilbert D. , Meinhof T. , Wirkner U. , Erfle H. , Muckenthaler M. , Pepperkok R. , Runz H. :Identification of cholesterol-regulating genes by targeted RNAi screening. Cell metabolism 10 2009 ), S. 63-75 ISSN: 1932-7420 10.1016/j.cmet.2009.05.009 Gilbert D. , Esmaeili A. , Lynch J. :Optimizing the expression of recombinant alphabetagamma GABAA receptors in HEK293 cells for high-throughput screening. Journal of Biomolecular Screening 14 2009 ), S. 86-91 ISSN: 1087-0571 10.1177/1087057108328017 Gilbert D. , Islam R. , Lynagh T. , Lynch J. , Webb T. :High Throughput Techniques for Discovering New Glycine Receptor Modulators and their Binding Sites. Frontiers in Molecular Neuroscience 2 2009 ), S. 17 ISSN: 1662-5099 10.3389/neuro.02.017.2009 Gilbert D. , Meinhof T. , Pepperkok R. , Runz H. :DetecTiff: a novel image analysis routine for high-content screening microscopy. Journal of biomolecular screening 14 2009 ), S. 944-55 ISSN: 1552-454X 10.1177/1087057109339523 Gilbert D. , Wilson J. , Nink V. , Lynch J. , Osborne G. :Multiplexed labeling of viable cells for high-throughput analysis of glycine receptor function using flow cytometry. Cytometry. Part A : the journal of the International Society for Analytical Cytology 75 2009 ), S. 440-9 ISSN: 1552-4930 10.1002/cyto.a.20703 Launikonis BS. , Stephenson DG. , Friedrich O. :Rapid Ca2+ flux through the transverse tubular membrane, activated by individual action potentials in mammalian skeletal muscle. The Journal of Physiology 587 2009 ), S. 2299-312 ISSN: 0022-3751 10.1113/jphysiol.2009.168682 http://onlinelibrary.wiley.com/doi/10.1113/jphysiol.2009.168682/full von Wegner F. , Schürmann S. , Fink R. , Vogel M. , Friedrich O. :Motor protein function in skeletal muscle-a multiple scale approach to contractility. IEEE transactions on medical imaging 28 2009 ), S. 1632-42 ISSN: 1558-254X 10.1109/TMI.2009.2026171 http://ieeexplore.ieee.org/xpl/articleDetails.jsp?arnumber=5153360
2008 2008
Friedrich O. :Critical illness myopathy: Sepsis-mediated failure of the peripheral nervous system European Journal of Anaesthesiology 25 2008 ), S. 73-82 ISSN: 0265-0215 10.1017/S0265021507003262 Friedrich O. , Weber C. , von Wegner F. , Chamberlain JS. , Fink R. :Unloaded speed of shortening in voltage-clamped intact skeletal muscle fibers from wt, mdx, and transgenic minidystrophin mice using a novel high-speed acquisition system. Biophysical Journal 94 2008 ), S. 4751-65 ISSN: 0006-3495 10.1529/biophysj.107.126557 http://www.cell.com/biophysj/abstract/S0006-3495%2808%2970342-4 Friedrich O. , von Wegner F. , Chamberlain JS. , Fink R. , Rohrbach P. :L-type Ca2+ channel function is linked to dystrophin expression in mammalian muscle. PLoS ONE 3 2008 ), S. e1762 ISSN: 1932-6203 10.1371/journal.pone.0001762 http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0001762 Schnee S. , von Wegner F. , Schürmann S. , Ludwig H. , Fink R. , Friedrich O. :Microdomain Ca2+ dynamics in mammalian muscle following prolonged high pressure treatments Journal of Physics : Conference Series 121 2008 ), Art.Nr.: 112003 ISSN: 1742-6588 10.1088/1742-6596/121/11/112003 Teichmann MDH. , von Wegner F. , Fink R. , Chamberlain JS. , Launikonis BS. , Martinac B. , Friedrich O. :Inhibitory control over Ca(2+) sparks via mechanosensitive channels is disrupted in dystrophin deficient muscle but restored by mini-dystrophin expression. PLoS ONE 3 2008 ), S. e3644 ISSN: 1932-6203 10.1371/journal.pone.0003644 http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0003644 von Wegner F. , Koyama S. , Miwa T. , Friedrich O. :Resting membrane potentials recorded on-site in intact skeletal muscles from deep sea fish (Sigmops gracile) salvaged from depths up to 1.000 m. Marine Biotechnology 10 2008 ), S. 478-86 ISSN: 1436-2228 10.1007/s10126-008-9085-x http://link.springer.com/article/10.1007/s10126-008-9085-x von Wegner F. , Ober T. , Weber C. , Schürmann S. , Winter R. , Friedrich O. , Fink R. , Vogel M. :Velocity distributions of single F-actin trajectories from a fluorescence image series using trajectory reconstruction and optical flow mapping. Journal of Biomedical Optics 13 2008 ), S. 054018 ISSN: 1083-3668 10.1117/1.2982525
2007 2007
Friedrich O. , von Wegner F. , Wink M. , Fink R. :NA+- and K+-channels as molecular targets of the alkaloid ajmaline in skeletal muscle fibres. British Journal of Pharmacology 151 2007 ), S. 82-93 ISSN: 0007-1188 10.1038/sj.bjp.0707194 http://onlinelibrary.wiley.com/doi/10.1038/sj.bjp.0707194/abstract;jsessionid=46E49C62B38C2F13EFC6BA6486CB62A6.f04t01 Gilbert D. , Franjic-Würtz C. , Funk K. , Gensch T. , Frings S. , Möhrlen F. :Differential maturation of chloride homeostasis in primary afferent neurons of the somatosensory system. International Journal of Developmental Neuroscience 25 2007 ), S. 479-89 ISSN: 0736-5748 10.1016/j.ijdevneu.2007.08.001 Gilbert D. , Funk K. , Dekowski B. , Lechler R. , Keller S. , Möhrlen F. , Frings S. , Hagen V. :Caged capsaicins: New tools for the examination of TRPV1 channels in somatosensory neurons. ChemBioChem 8 2007 ), S. 89-97 ISSN: 1439-4227 10.1002/cbic.200600437 Völkers M. , Loughrey CM. , MacQuaide N. , Remppis BA. , DeGeorge BR. , von Wegner F. , Friedrich O. , Fink R. , Koch WJ. , Smith GL. , Most P. :S100A1 decreases calcium spark frequency and alters their spatial characteristics in permeabilized adult ventricular cardiomyocytes. Cell Calcium 41 2007 ), S. 135-43 ISSN: 0143-4160 10.1016/j.ceca.2006.06.001 http://www.sciencedirect.com/science/article/pii/S0143416006001138 von Wegner F. , Both M. , Fink R. , Friedrich O. :Fast XYT imaging of elementary calcium release events in muscle with multifocal multiphoton microscopy and wavelet denoising and detection. IEEE Transactions on Medical Imaging 26 2007 ), S. 925-34 ISSN: 0278-0062 10.1109/TMI.2007.895471 http://ieeexplore.ieee.org/xpl/articleDetails.jsp?arnumber=4265757
2006 2006
Friedrich O. :Critical illness myopathy: What is happening? Current Opinion in Clinical Nutrition and Metabolic Care 9 2006 ), S. 403-409 ISSN: 1363-1950 10.1097/01.mco.0000232900.59168.a0 Friedrich O. , Hund E. :Critical illness myopathy in intensive care patients: Pathogenetic concepts and clinical management Anaesthesist 55 2006 ), S. 1271-1280 ISSN: 0003-2417 10.1007/s00101-006-1100-x Friedrich O. , Kress K. , Hartmann M. , Frey B. , Sommer K. , Ludwig H. , Fink R. :Prolonged high-pressure treatments in mammalian skeletal muscle result in loss of functional sodium channels and altered calcium channel kinetics. Cell Biochemistry and Biophysics 45 2006 ), S. 71-83 ISSN: 1085-9195 10.1385/CBB:45:1:71 Friedrich O. , von Wegner F. , Hartmann M. , Frey B. , Sommer K. , Ludwig H. , Fink R. :'In situ' high pressure confocal Ca2+-fluorescence microscopy in skeletal muscle: A new method to study pressure limits in mammalian cells Undersea & Hyperbaric Medicine 33 2006 ), S. 181-95 ISSN: 1066-2936 https://www.scopus.com/record/display.uri?eid=2-s2.0-33746618017∨igin=inward Rohrbach P. , Sanchez CP. , Hayton K. , Friedrich O. , Patel J. , Singh Sidhu AB. , Ferdig MT. , Fidock DA. , Lanzer M. :Genetic linkage of pfmdr1 with food vacuolar solute import in Plasmodium falciparum. EMBO Journal 25 2006 ), S. 3000-11 ISSN: 0261-4189 10.1038/sj.emboj.7601203 Sinner B. , Friedrich O. , Zink W. , Fink R. , Graf B. :GABAmimetic intravenous anaesthetics inhibit spontaneous Ca 2+-oscillations in cultured hippocampal neurons Acta Anaesthesiologica Scandinavica 50 2006 ), S. 742-748 ISSN: 0001-5172 10.1111/j.1399-6576.2006.01031.x von Wegner F. , Both M. , Fink R. , Friedrich O. :Elementary Ca2+ release events in mammalian skeletal muscle: effects of the anaesthetic drug thiopental. Journal of Muscle Research and Cell Motility 27 2006 ), S. 315-26 ISSN: 0142-4319 10.1007/s10974-006-9092-3
2005 2005
Friedrich O. , Fink R. , Hund E. :Understanding critical illness myopathy: approaching the pathomechanism. Journal of Nutrition 135 2005 ), S. 1813S-1817S ISSN: 0022-3166 10.1093/jn/135.7.1813S Kruger W. , Gilbert D. , Hawthorne R. , Hryciw D. , Frings S. , Poronnik P. , Lynch J. :A yellow fluorescent protein-based assay for high-throughput screening of glycine and GABAA receptor chloride channels. Neuroscience Letters 380 2005 ), S. 340-5 ISSN: 0304-3940 10.1016/j.neulet.2005.01.065 Nolte F. , Friedrich O. , ROjewski M. , Fink R. , Schrezenmeier H. , Körper S. :Erratum: Depolarisation of the plasma membrane in the arsenic trioxide (As2O3)- and anti-CD95-induced apoptosis in myeloid cells (FEBS 29005) (FEBS Letters (2004) 578 (85-89) DOI 10.1016/j.febslet.2004.10.075) Febs Letters 579 2005 )ISSN: 0014-5793 10.1016/j.febslet.2005.05.037 Rohrbach P. , Friedrich O. , Hentschel J. , Plattner H. , Fink R. , Lanzer M. :Quantitative calcium measurements in subcellular compartments of Plasmodium falciparum-infected erythrocytes Journal of Biological Chemistry 280 2005 ), S. 27960-27969 ISSN: 0021-9258 10.1074/jbc.M500777200 Sinner B. , Friedrich O. , Zink W. , Martin EO. , Fink R. , Graf BM. :Ketamine stereoselectively inhibits spontaneous Ca2+-oscillations in cultured hippocampal neurons. Anesthesia and Analgesia 100 2005 ), S. 1660-6 ISSN: 0003-2999 10.1213/01.ANE.0000150946.18875.48
2004 2004
Both M. , Vogel M. , Friedrich O. , von Wegner F. , Künsting T. , Fink R. , Uttenweiler D. :Second harmonic imaging of intrinsic signals in muscle fibers in situ. Journal of Biomedical Optics 9 2004 ), S. 882-92 ISSN: 1083-3668 10.1117/1.1783354 Friedrich O. , Both M. , Gillis JM. , Chamberlain JS. , Fink R. :Mini-dystrophin restores L-type calcium currents in skeletal muscle of transgenic mdx mice. The Journal of Physiology 555 2004 ), S. 251-65 ISSN: 0022-3751 10.1113/jphysiol.2003.054213 Friedrich O. , Hund E. , Weber C. , Hacke W. , Fink R. :Critical illness myopathy serum fractions affect membrane excitability and intracellular calcium release in mammalian skeletal muscle. Journal of Neurology 251 2004 ), S. 53-65 ISSN: 0340-5354 10.1007/s00415-004-0272-z Nessler S. , Friedrich O. , Bakouh N. , Fink R. , Sanchez CP. , Planelles G. , Lanzer M. :Evidence for activation of endogenous transporters in Xenopus laevis oocytes expressing the Plasmodium falciparum chloroquine resistance transporter, PfCRT. Journal of Biological Chemistry 279 2004 ), S. 39438-46 ISSN: 0021-9258 10.1074/jbc.M404671200 Nolte F. , Friedrich O. , ROjewski M. , Fink R. , Schrezenmeier H. , Körper S. :Depolarisation of the plasma membrane in the arsenic trioxide (As2O3)-and anti-CD95-induced apoptosis in myeloid cells. Febs Letters 578 2004 ), S. 85-9 ISSN: 0014-5793 10.1016/j.febslet.2004.10.075
2001 2001
Friedrich O. , Ehmer T. , Uttenweiler D. , Vogel M. , Barry PH. , Fink R. :Numerical analysis of Ca2+ depletion in the transverse tubular system of mammalian muscle. Biophysical Journal 80 2001 ), S. 2046-55 ISSN: 0006-3495 10.1016/S0006-3495(01)76178-4 Friedrich O. , Kress K. , Ludwig H. , Fink R. :Reversibility of high pressure effects on the contractility of skeletal muscle. Journal of Muscle Research and Cell Motility 22 2001 ), S. 379-89 ISSN: 0142-4319
