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High-throughput Biology & Robophotonics

Our research focuses on the development and application of novel approaches in cell-based high-throughput screening for studying neuronal mechanisms in homeostasis, development and disease. We engineer instruments using rapid prototyping approaches and develop computational tools for analysis of phenotypic data sets from automated high-content fluorescence imaging. We design miniaturized assay formats for massively parallelized microscopy of single cells as well as in-vitro models promoting the 3Rs concept (Reduction, Refinement & Replacement) in animal experimentation and we apply our technologies for e.g. studying neurotransmission, pharmacology and toxicity using chemical and genetic libraries.