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Institute of Medical Biotechnology
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  1. Friedrich-Alexander-Universität
  2. Technische Fakultät
  3. Department Chemie- und Bioingenieurwesen

Institute of Medical Biotechnology

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  5. Characterization of drug-resistance transporters of the digestive vacuole

Characterization of drug-resistance transporters of the digestive vacuole

Bereichsnavigation: Research
  • Research Groups
    • Muscle Opto-Biomechatronics
      • The MyoRobot
      • The MechaMorph
      • The IsoStretcher
      • Virtual Laboratory
    • Malaria Biotechnology
      • RG Protein Engineering
      • Metabolic enzymes as drug targets
      • Identification of novel antimalarial compounds
      • Mitosis as drug target
      • Identification of transporters of the MGC-basic proteins
      • Characterization of drug-resistance transporters of the digestive vacuole
      • Malaria vaccine directed against blood stages
    • Tissue Engineering
      • Bone Tissue Engineering
      • Research Topic 2 (TE)
      • Research Topic 3 (TE)
    • Optical Technologies in Life Sciences
      • Label-free Multiphoton Imaging
      • Multiphoton Endomicroscopy for Life Science and Medicine
      • Raman Spectroscopy of Biological Tissue
      • PiezoGRIN: Multiphoton Imaging under high Pressures
    • High-throughput Biology & Robophotonics
      • High-throughput Biology & Functional Neurogenomics
      • Robophotonics & Rapid Prototyping
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Characterization of drug-resistance transporters of the digestive vacuole

Group Leader

Nina Simon

Dr. Nina Simon

Group Leader

Medical Biotechnology
Malaria Biotechnology

Raum: Room 00.115
Ulrich-Schalk-Str. 3
91056 Erlangen
Germany
  • Telefon: +49913185-69657
  • E-Mail: nina.simon@fau.de

Malaria treatment options have become complicated within the last decade through spontaneous mutations in the genome of the parasite involving genes encoding for drug resistance transporters. The digestive vacuole represents an organelle (DV, labelled in green in the picture, parasite in red, nucleus in blue) within the malaria parasite where host hemoglobin of the infected red blood cell (iRBC) is digested and biomineralized to hemozoin, a biocrystal inert to the parasite. Several antimalarial drugs have been suggested to inhibit this biomineralization, resulting in heme accumulation to levels that are toxic to the parasite. However, mutations in membrane transporters localized in the DV membrane affected drug influx or efflux activity, thus protecting the parasite from drug action (Reiling et al., 2018; Friedrich et al., 2014). Together with our collaboration partner Prof. Dr. Petra Rohrbach from the McGill University in Montreal, we determine flux rates and the ability of the transporters to convey new potential drugs in order to predict early upcoming resistances.

Friedrich-Alexander-Universität
Erlangen-Nürnberg

Schlossplatz 4
91054 Erlangen
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